This continuation application demonstrates the presence of all the requirements for our Center to remain a key Network member. We have been a productive member of all Network functions including study design, patient recruitment, manuscript preparation, committee membership and leadership. We have demonstrated the ability to collaborate in a collegial manner with other Network centers. We have also been productive beyond the confines of the Network in terms of collaborative studies, bench and clinical research as well as publications. There are 15 Board certified academic neonatologists who ensure protected time for Network activities. Each year we admit more than 1000 babies to the NICU, including approximately 200 with birth weights < 1.5 kg. The adjacent obstetric service delivers almost 5000 babies each year, many high risk, and is supported by four maternal-fetal specialists with interest in clinical research and commitment to the Network concept. Our subspeciality designated (former level III) perinatal center includes modern facilities for labor and delivery, neonatal intensive care and convalescent care. There is a full complement of pediatric medical and surgical subspecialities together with strongly nationally recognized programs in respiratory therapy, nursing, pharmacy, genetics, nutrition, radiology and pediatric pathology. These is a biochemistry, hematology, immunology and microbiology laboratory together with a full service blood bank. The Radiology Department is equipped with standard radiography and the latest generation of ultrasound, CT scanning, MR and PET scanners. Our follow-up program has been nationally acclaimed and boasts in excess of 90% follow-up rate for study patients. The computerized neonatal/perinatal and follow-up data systems have supported a number of studies. We have transmitted our data to the Data Center in a timely and accurate manner. Our experienced nurse coordinator and clinical research nurse team ensure high enrollment rates and compliance with protocols. There is a firm divisional, departmental and institutional commitment to participate in a collaborative manner with other centers. CWRU is proud of its record within the Network and strongly desires to continue to participate. We accept the budgetary process and have submitted an exciting concept protocol for consideration by the Network. In summary, we comfortably satisfy all the criteria for Network participation. We have the personnel, the facilities, the patient base, the data bases and, above all, the experience and commitment. We have firm institutional backing, have demonstrated remarkable productivity and the ability to collaborate, hence fulfill all Network selection criteria.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD021364-17
Application #
6520808
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (10))
Program Officer
Wright, Linda
Project Start
1986-04-01
Project End
2006-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
17
Fiscal Year
2002
Total Cost
$369,940
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Brumbaugh, Jane E; Colaizy, Tarah T; Saha, Shampa et al. (2018) Oral feeding practices and discharge timing for moderately preterm infants. Early Hum Dev 120:46-52
Natarajan, Girija; Shankaran, Seetha; Saha, Shampa et al. (2018) Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants. J Pediatr 195:66-72.e3
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Bajaj, Monika; Natarajan, Girija; Shankaran, Seetha et al. (2018) Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants. J Pediatr 195:33-38.e2
Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445

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