The Wayne State University School of Medicine at the Detroit Medical Center is submitting an application for renewal in the NICHD Multicenter Neonatal Research Network. The Division of Neonatal-Perinatal Medicine has both an inborn service at Hutzel Hospital (6000 deliveries, 55 bed NICU/Progressive Care Nursery) and an outborn service at Children?s Hospital of Michigan (45 bed NICU). The Division of Maternal-Fetal Medicine at Wayne State is currently a member of the NICHD Multicenter Materna/-Fetal Research Network (MFM). The Division of Clinical Pharmacology at Wayne State is currently a member of the NICHD Pediatric Pharmacology Research Unit (PPRU). The Wayne State site has additional capabilities of including two more Detroit Medical Center inborn hospitals (Sinai-Grace Hospital, 4000 deliveries and Huron Valley Hospital, 2000 deliveries) into the Neonatal Research Network with the site PI who is the Regional Director of the Detroit Medical Center?s Neonatal Programs. The Wayne State site has actively participated in the current NICHD Neonatal Research Network studies by contributing a greater number of subjects than the average enrollment per site. These studies include 1134 subjects enrolled in the Generic Database Study, 366 in the Follow-up Study, 28 in the Erythropoiten Study, 157 in the Magnesium Sulfate Study, and 61 in the Vitamin A Study. In two studies, the Wayne State site has far exceeded enrollment. These include the Early Inhaled Nitric Oxide Study, Wayne State has enrolled 32 of 203 subjects and the Network study on Hypothermia for Encephalopathy where Wayne State has enrolled 4 of 22 subjects. In the Maternal Lifestyle Study (4 sites), Wayne State has enrolled 43% of all infants enrolled in Phase II and III of the study. I n the current grant period, the Principal Investigator at the Wayne State University site, Dr. Seetha Shankaran, served as PI for the Antenatal Phenobarbital to Prevent IVH Study and is currently PI of the Induced Hypothermia for Encephalopathy Study. Strengthens of the Wayne State site include neonatal imagining abilities (PET and MRI), obstetric imaging capabilities, the fetal diagnosis and therapy program and ongoing collaboration with the NICHD MFMU Network and the NICHD PPRU Network.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10HD021385-16
Application #
6331376
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (10))
Program Officer
Wright, Linda
Project Start
1991-04-01
Project End
2006-03-31
Budget Start
2001-06-01
Budget End
2002-03-31
Support Year
16
Fiscal Year
2001
Total Cost
$424,720
Indirect Cost
Name
Wayne State University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
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Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Chawla, Sanjay; Natarajan, Girija; Chowdhury, Dhuly et al. (2018) Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids. Am J Perinatol 35:1213-1221
Brumbaugh, Jane E; Colaizy, Tarah T; Saha, Shampa et al. (2018) Oral feeding practices and discharge timing for moderately preterm infants. Early Hum Dev 120:46-52
Natarajan, Girija; Shankaran, Seetha; Saha, Shampa et al. (2018) Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants. J Pediatr 195:66-72.e3
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
James, Jennifer; Munson, David; DeMauro, Sara B et al. (2017) Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr 190:118-123.e4

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