The Wake Forest University MFMU Center is reapplying for participation in the MFMU Network. The strengths of this Center include: (1) The Center has a large stable base of ethnically diverse obstetrical patients and deliveries by virtue of the fact that the hospital at which the Center is based, Forsyth Medical Center, is the only hospital delivering in-patient obstetric care for a four county area. A high proportion of these patients are high-risk patients since the unit is the only tertiary perinatal center for a 17 county area in Northwest North Carolina; (2) The Wake Forest University Center has had a strong record of participation in the Network for the past nine years. It has a solid record in design of protocols (it is the lead Center for an active MFMU Network protocol), in recruitment of subjects, and in accuracy and reliability of data collection. The Center?s investigators appear as authors on 33 Network publications; (3) The Center?s Principal Investigator, Dr. Paul Meis, has played an important role in the activities of the Network as Chair of the Publications Committee and of the Progesterone Subcommittee. He has worked closely with the Program Officer and the Biostatistical Center to facilitate high quality publications of the work of the Network; and (4) The Wake Forest University Center has unusual potential for epidemiologic research. The fact that it is the only tertiary perinatal center for seventeen counties facilitates the performance of geographically based studies of maternal and infant epidemiology. Dr. Meis and Dr. T. Michael O?Shea, the neonatal consultant, have special interest in this area and have collaborated on studies in the past using a combined perinatal-neonatal database. Drs. Meis and O Shea have been active in the leadership of the Society for Pediatric and Perinatal Epidemiologic Research. Dr. O?Shea is submitting an application for participation of Wake Forest University in the NICHD Neonatal Network.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10HD027860-15S1
Application #
7275882
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Spong, Catherine
Project Start
1991-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2008-03-31
Support Year
15
Fiscal Year
2006
Total Cost
$58,200
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Bustos, Martha L; Caritis, Steve N; Jablonski, Kathleen A et al. (2017) The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth. Am J Obstet Gynecol 217:369.e1-369.e9
Tita, Alan T N; Lai, Yinglei; Landon, Mark B et al. (2017) Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. Am J Perinatol 34:1464-1469
Silver, Robert M; Myatt, Leslie; Hauth, John C et al. (2017) Cell-Free Total and Fetal DNA in First Trimester Maternal Serum and Subsequent Development of Preeclampsia. Am J Perinatol 34:191-198
Hughes, Brenna L; Clifton, Rebecca G; Hauth, John C et al. (2016) Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data. Am J Perinatol 33:983-90
Landon, Mark B; Grobman, William A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network (2016) What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry. Semin Perinatol 40:281-6
Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17
Basraon, Sanmaan K; Mele, Lisa; Myatt, Leslie et al. (2016) Relationship of Early Pregnancy Waist-to-Hip Ratio versus Body Mass Index with Gestational Diabetes Mellitus and Insulin Resistance. Am J Perinatol 33:114-21
Wapner, Ronald J; Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A et al. (2016) What we have learned about antenatal corticosteroid regimens. Semin Perinatol 40:291-7

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