This is a competitive renewal application by researchers at Ohio State University for continuing participation in the fifth iteration of the NICHD Maternal Fetal Medicine Units Network. The Network is a collaborative clinical research consortium that operates under a cooperative agreement between NICHD and participating centers that have been selected through re-competition every five years since 1986. The mission of the MFMU Network is to improve fetal and maternal outcomes through clinical research in obstetrics. Particular attention is directed to disorders that lead to preterm, low birth weight, and/or neurologically damaged infants, to the introduction of new technology into obstetrical care, and to maternal medical disorders. Problems that affect newborn infants often have their origins in pregnancy, and cause lifelong consequences such as cerebral palsy, mental retardation, hearing and vision loss, and poor school performance. Reducing the frequency and severity of the disorders addressed by MFMU Network research has the potential to improve health throughout the Irfespan of the children affected by these disorders. The Network seeks to achieve these goals through large multi-center interventional and observational clinical studies to assess the safety, efficacy and cost-effectiveness of current and new management protocols. The Network has performed randomized placebo-controlled trials of medications to prevent pre-eclampsia, preterm birth, and related morbidities such as cerebral palsy in preterm infants. The Network has also studied risk factors for preterm birth, cesarean section, asthma, and diabetes in pregnancy. Ohio State University has contributed substantially to these trials since joining the Network in 1992. This application contains a summary of contributions from Ohio State to past and current Network research, a description of the current facilities and population available at Ohio State for enrollment into current and future studies, and a concept proposal for a Network observational study that will assess the effect of stress on inflammation as a mechanism to explain racial and ethnic disparities in the rate of preterm birth.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD027915-20
Application #
8033151
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (23))
Program Officer
Spong, Catherine
Project Start
1992-04-08
Project End
2011-03-31
Budget Start
2010-12-01
Budget End
2011-03-31
Support Year
20
Fiscal Year
2011
Total Cost
$85,264
Indirect Cost
Name
Ohio State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Pasko, Daniel N; McGee, Paula; Grobman, William A et al. (2018) Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol 131:1039-1048
Tita, Alan T N; Jablonski, Kathleen A; Bailit, Jennifer L et al. (2018) Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 219:296.e1-296.e8
Grobman, William A; Bailit, Jennifer; Sandoval, Grecio et al. (2018) The Association of Decision-to-Incision Time for Cesarean Delivery with Maternal and Neonatal Outcomes. Am J Perinatol 35:247-253
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Kominiarek, Michelle A; Saade, George; Mele, Lisa et al. (2018) Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol 132:875-881
Kominiarek, Michelle A; Smid, Marcela C; Mele, Lisa et al. (2018) Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol 132:1386-1393
Varner, Michael W; Mele, Lisa; Casey, Brian M et al. (2018) Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. J Perinatol 38:1490-1495

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