description): This is an application for continued participation as the Data Coordinating and Analysis Center in an extended Collaborative Home Infant Monitoring Evaluation (CHIME) Study over the next five years. Each year, approximately 50,000 infants are placed on a home cardiorespiratory (CR) monitor. Monitors are typically prescribed for infants in one of three groups at increased risk for Sudden Infant Death Syndrome (SIDS): infants who experience an idiopathic apparent life-threatening event (apnea of infancy, AO1), SIDS siblings, and preterm infants. Despite years of experience, it is not known to what extent monitor use has reduced either infant morbidity or mortality. The CHIME study is designed to address the unresolved questions regarding who has CR events at home, the nature of these events, and their impact on neurodevelopmental outcome. We propose a 5-year extension of the CHIME study in order to complete enrollment, follow-up, and data analysis. A total of 2,115 infants will be enrolled: 375 healthy term infants, 330 SIDS siblings, 330 with AO1, and 1,080 preterm infants < 1750 g birth weight. Each infant will receive an overnight polysonogram and will be monitored at home for 4-5 months using a memory monitor developed for the CHIME study. The monitor will store all CR events occurring at home and the associated oxygen saturation and sleep position, will record periodic non-event (normative) intervals, and will continuously record R-R and breath-to-breath intervals. Apneas will be categorized as central, mixed or obstructive by the use of inductance plethysmography, a technique not previously available for home monitoring. Clinical and neurodevelopmental status will be ascertained longitudinally through 1 year of age. The CHIME study will create a comprehensive summary of the full range of CR events occurring in the home. The results will yield important insights regarding underlying mechanisms, antecedent variables predictive of events, appropriate intervention strategies, and the relationship between CR events and neurodevelopmental outcome.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10HD029067-08S1
Application #
6317499
Study Section
Special Emphasis Panel (SRC (CI))
Program Officer
Spong, Catherine
Project Start
1991-09-30
Project End
2002-08-31
Budget Start
1998-09-01
Budget End
2002-08-31
Support Year
8
Fiscal Year
2000
Total Cost
$92,113
Indirect Cost
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Shapiro-Mendoza, Carrie K; Colson, Eve R; Willinger, Marian et al. (2015) Trends in infant bedding use: National Infant Sleep Position study, 1993-2010. Pediatrics 135:10-7
Colson, Eve R; Willinger, Marian; Rybin, Denis et al. (2013) Trends and factors associated with infant bed sharing, 1993-2010: the National Infant Sleep Position Study. JAMA Pediatr 167:1032-7
Lister, George; Rybin, Denis V; Colton, Theodore et al. (2012) Relationship between sleep position and risk of extreme cardiorespiratory events. J Pediatr 161:22-5.e1
Hunt, Carl E; Corwin, Michael J; Weese-Mayer, Debra E et al. (2011) Longitudinal assessment of hemoglobin oxygen saturation in preterm and term infants in the first six months of life. J Pediatr 159:377-383.e1
Von Kohorn, Isabelle; Corwin, Michael J; Rybin, Denis V et al. (2010) Influence of prior advice and beliefs of mothers on infant sleep position. Arch Pediatr Adolesc Med 164:363-9
Smith, Lauren A; Colson, Eve R; Rybin, Denis et al. (2010) Maternal assessment of physician qualification to give advice on AAP-recommended infant sleep practices related to SIDS. Acad Pediatr 10:383-8
Colson, Eve R; Rybin, Denis; Smith, Lauren A et al. (2009) Trends and factors associated with infant sleeping position: the national infant sleep position study, 1993-2007. Arch Pediatr Adolesc Med 163:1122-8
Fu, Linda Y; Colson, Eve R; Corwin, Michael J et al. (2008) Infant sleep location: associated maternal and infant characteristics with sudden infant death syndrome prevention recommendations. J Pediatr 153:503-8
Robb, Michael P; Crowell, David H; Dunn-Rankin, Peter (2007) Cry analysis in infants resuscitated for apnea of infancy. Int J Pediatr Otorhinolaryngol 71:1117-23
Colson, Eve R; Levenson, Suzette; Rybin, Denis et al. (2006) Barriers to following the supine sleep recommendation among mothers at four centers for the Women, Infants, and Children Program. Pediatrics 118:e243-50

Showing the most recent 10 out of 11 publications