This proposal will demonstrate the capabilities of Oregon Health & Science University (OHSU) to continue being part of the Eunice Kennedy Shriver Maternal Fetal Medicine Units Network of the NICHD. OHSU has been an active participant in the MFMUN for the last 5 years. We have demonstrated capabilities to propose novel research protocols and to cooperate in all activities related to all ongoing clinical trials in the MFMUN. We have recruited participants in all the protocols. We have served on subcommittees for new protocols and have provided intellectual input into their development. We have published original manuscripts and presented posters at national meetings and attended all the meetings of the Steering Committee. We have managed a complex collaboration with other sites that are part of our center and have effectively coordinated collection and transfer of data from our center to the NICHD. We are proposing a novel concept project entitled RCT of Contingency Management for Smoking Cessation in Pregnancy. This proposal addresses with innovation the most important complication of pregnancy in the U.S., preterm birth. OHSU has demonstrated capabilities and scientific leadership in research in this topic. Our Division of Maternal Fetal Medicine is composed of 8 specialists in MFM, 1 MFM-geneticist, 3 fellows, 2 OB/GYN investigators one focused on clinical effectiveness, one on advanced fetal echocardiography and 5 scientists. In addition to the faculty, our research support group includes 4 research nurses, a general Ob/GYN and 3 research associates. OHSU is the only teaching center in the State of Oregon. It provides state of the art obstetric services with 2557 deliveries in 2009; 36% were considered high risk. This application includes participation of the Providence-Sacred Heart Medical Center (PSHMC) in Spokane, Washington, site which was added to our Center in July 2008. PSHMC has been successful in all activities related to recruitment of participants into the protocols authorized by NICHD. It is the largest provider of obstetric services in the Inland Northwest region of the U.S. with 2704 in 2009 deliveries of which 32% were high risk, for a total number of 5261 deliveries a year at our center.

Public Health Relevance

Participation of OHSU in the MFMUN will bring discoveries made by this research initiative into clinical practice in Oregon and Washington, with tangible improvement in public health. These centers provide training to hundreds of students and direct medical care to thousands of women, their babies and families. We will further improve, prevent and reduce adverse outcomes of pregnancy, preterm birth, low birth weight, maternal morbidity and mortality in large urban and rural areas of the Pacific Northwest of the U.S.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD053118-11
Application #
8903983
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Miodovnik, Menachem
Project Start
2006-05-25
Project End
2017-03-31
Budget Start
2015-04-01
Budget End
2017-03-31
Support Year
11
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Pasko, Daniel N; McGee, Paula; Grobman, William A et al. (2018) Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol 131:1039-1048
Tita, Alan T N; Jablonski, Kathleen A; Bailit, Jennifer L et al. (2018) Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 219:296.e1-296.e8
Grobman, William A; Bailit, Jennifer; Sandoval, Grecio et al. (2018) The Association of Decision-to-Incision Time for Cesarean Delivery with Maternal and Neonatal Outcomes. Am J Perinatol 35:247-253
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Kominiarek, Michelle A; Saade, George; Mele, Lisa et al. (2018) Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol 132:875-881
Kominiarek, Michelle A; Smid, Marcela C; Mele, Lisa et al. (2018) Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol 132:1386-1393
Varner, Michael W; Mele, Lisa; Casey, Brian M et al. (2018) Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. J Perinatol 38:1490-1495
Chauhan, Suneet P; Rice, Madeline Murguia; Grobman, William A et al. (2017) Neonatal Morbidity of Small- and Large-for-Gestational-Age Neonates Born at Term in Uncomplicated Pregnancies. Obstet Gynecol 130:511-519
Tita, Alan T N; Lai, Yinglei; Landon, Mark B et al. (2017) Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. Am J Perinatol 34:1464-1469

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