The Investigator and his collaborators propose to establish an ACRN Center at Harlem Hospital. This hospital already is the site for the HART, a group of investigators which have been working together for the past 5 years in order to determine the reasons for high asthma morbidity and mortality in the Harlem community. As a result of the presence of this team two parallel administrative structures exist. These include a group of physicians who have worked together closely under the leadership of Dr. Ford to identify people of color in the Harlem area who have asthma, recruit them into clinical studies, and use the data derived from these studies to further their understanding of asthma. In parallel with this group of physicians, an administrative structure of clinical research personnel and advisors has been assembled which provides the needed support for the physicians to complete their scientific goals successfully. The investigators have established a liaison with the practicing physicians within the Harlem community, most of whom are part of the Renaissance Capital Health Care Network, as well as the practitioners within the Harlem Hospital complex. The latter are important as they comprise the largest number of physicians seeing asthma patients within the Harlem community on a regular basis. Through a closely established liaison with these physician groups, patients with asthma have been shown to be recruitable for observational clinical trials. In these activities the group has demonstrated its experience recruiting patients, gathering data from them, and handling the data. The investigators already have a clinical facility established for the HART program which is equipped for pulmonary function testing. That provides a physical location where the ACRN component at Harlem Hospital can be located. Through the REACH (Reducing Emergency Asthma Care in Harlem) program they have established a clinical research coordinator and data acquisition system. They have demonstrated their experience in following patients with asthma by peak flow monitoring in the Chest Clinic at Harlem Hospital, as well as experience with quality of life measures in diseases other than asthma. The investigators have outlined plans to allow them to use standard asthma quality of life indicators in their community. Finally, detailed plans are given on how an intervention trial research network will be established and how practical advice from others will be solicited and used.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HL056443-02
Application #
2030065
Study Section
Special Emphasis Panel (ZHL1-CCT-H (O1))
Project Start
1995-12-08
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Israel, Elliot; Lasky-Su, Jessica; Markezich, Amy et al. (2015) Genome-wide association study of short-acting ?2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med 191:530-7
Lambert, Allison; Drummond, M Bradley; Wei, Christine et al. (2015) Diagnostic accuracy of FEV1/forced vital capacity ratio z scores in asthmatic patients. J Allergy Clin Immunol 136:649-653.e4
Wang, Y; Tong, C; Wang, Z et al. (2015) Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma. Pharmacogenomics J 15:422-9
Dunn, Ryan M; Lehman, Erik; Chinchilli, Vernon M et al. (2015) Impact of Age and Sex on Response to Asthma Therapy. Am J Respir Crit Care Med 192:551-8
Gelman, Rony; DiMango, Emily A; Schiff, William M (2013) Sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia. Retin Cases Brief Rep 7:362-7
Tantisira, Kelan G; Damask, Amy; Szefler, Stanley J et al. (2012) Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. Am J Respir Crit Care Med 185:1286-91
Szefler, Stanley J; Chinchilli, Vernon M; Israel, Elliot et al. (2012) Key observations from the NHLBI Asthma Clinical Research Network. Thorax 67:450-5
Wechsler, Michael E; Castro, Mario; Lehman, Erik et al. (2011) Impact of race on asthma treatment failures in the asthma clinical research network. Am J Respir Crit Care Med 184:1247-53
Sutherland, E Rand; Lehman, Erik B; Teodorescu, Mihaela et al. (2009) Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol 123:1328-34.e1
Qian, Zhengmin; Lin, Hung-Mo; Chinchilli, Vernon M et al. (2009) Associations between air pollution and peak expiratory flow among patients with persistent asthma. J Toxicol Environ Health A 72:39-46

Showing the most recent 10 out of 26 publications