Issues of therapeutic efficacy, contraindications, adverse events and costs are now of paramount importance in medical practice. The current role of clinical investigation includes the ability to gather evidence from a variety of sources, to synthesize results from multiple studies, and to translate clinical findings into practice. A research center that has experience and capabilities in each of these areas and can bring together the multidisciplinary resources to address important clinical issues in a timely manner could make a valuable contribution to medical practice. We propose to establish a comprehensive and efficient Research Center to investigate clinical therapeutics in cardiovascular medicine. This Center will provide vision, leadership, and direction to the synthesis and dissemination of knowledge in this area. Our ultimate goal is to develop and implement strategies to translate these clinical findings into improved practice. We also propose to function as the coordinating center for all of the centers funded by this mechanism. Our overall objective is to improve the quality of medical care for cardiology patients by completing the following 6 Specific Aims, briefly stated as:
Specific Aim 1 : Continue our current efforts in this area.
Specific Aim 2 : Maintain a center for the systematic aggregation of data about currently approved therapies in the area of cardiovascular medicine Specific Aim 3: Complete 3 demonstration projects on improved use of new drugs using an integrated health system.
Specific Aim 4 : Work with FDA on specific surveillance programs for CV devices Specific Aim 5: Disseminate the results of the Center.
Specific Aim 6 : Use the Center to continue to attract additional funding in this area.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Demonstration--Cooperative Agreements (U18)
Project #
3U18HS010548-03S2
Application #
6647458
Study Section
Special Emphasis Panel (ZHS1 (01))
Program Officer
Bosco, Lynn
Project Start
1999-09-30
Project End
2002-09-29
Budget Start
2001-09-30
Budget End
2002-09-29
Support Year
3
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Vavalle, John P; Lopes, Renato D; Chen, Anita Y et al. (2012) Hospital length of stay in patients with non-ST-segment elevation myocardial infarction. Am J Med 125:1085-94
Calvert, Sara Bristol; Kramer, Judith M; Anstrom, Kevin J et al. (2012) Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial. Am Heart J 163:657-65.e1
Greiner, Melissa A; Hammill, Bradley G; Fonarow, Gregg C et al. (2012) Predicting costs among medicare beneficiaries with heart failure. Am J Cardiol 109:705-11
Alexander, Karen P; Wang, Tracy Y; Li, Shuang et al. (2011) Randomized trial of targeted performance feedback to facilitate quality improvement in acute myocardial infarction care. Circ Cardiovasc Qual Outcomes 4:129-35
Patterson, Mark E; Hernandez, Adrian F; Hammill, Bradley G et al. (2010) Process of care performance measures and long-term outcomes in patients hospitalized with heart failure. Med Care 48:210-6
Hernandez, Adrian F; Hammill, Bradley G; Peterson, Eric D et al. (2010) Relationships between emerging measures of heart failure processes of care and clinical outcomes. Am Heart J 159:406-13
Tricoci, Pierluigi; Allen, Joseph M; Kramer, Judith M et al. (2009) Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA 301:831-41
LaPointe, Nancy M Allen; Stafford, Judith A; Pappas, Paul A et al. (2009) Use of beta-blockers in patients with an implantable cardioverter defibrillator. Ann Pharmacother 43:1189-96
Hammill, Bradley G; Hernandez, Adrian F; Peterson, Eric D et al. (2009) Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. Am Heart J 157:995-1000
Allen LaPointe, Nancy M; Zhou, Yi; Stafford, Judith A et al. (2009) Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease. Am J Cardiol 103:1518-24

Showing the most recent 10 out of 14 publications