This UW STI TM CRC application includes 4 interrelated Projects, 2 scientific Cores (Biostatistics and Laboratory), and an STI TM CRC Developmental Awards Program. The First Project, Comparative Genomics of Clinical C. trachomatis Strains (Daniel Rockey) will use the Lab Core's large specimen repository to explore linkages of chlamydial genotypes to three unique phenotypes of C. trachomatis, seeking chlamydial genes important in previously uncharacterized aspects of chlamydial biology and pathogenesis. The Second Project, Immunogenetic Correlates of Severity of Genital HSV-2 Infection (Anna Wald) will identify MHC class I and II alleles associated with HSV-2 infection severity, and determine how HLA class I-restricted CMI responses exert selective pressures on HSV-2 amino acid sequences. The Third Project, Male Microbicide Safety Acceptance & Efficacy Against STI (King Holmes) plans preclinical studies, a Phase 1 trial, and a Phase 2/3 double-blinded placebo-controlled randomized controlled trial (RCT) in Kenya of 62% ethanol in emollient gel for preventing STI acquisition by men. This promising topical microbicide is nontoxic, preferred for hand hygiene in health care settings, widely available over-the-counter for domestic use, and has been well tolerated in our NIH-funded preparatory studies in Nairobi. The Fourth Project, M. genitalium Susceptibility and Treatment (Lisa Manhart) proposes development of innovative methods to measure antimicrobial susceptibility of M. genitalium, and a double blinded, placebo-controlled RCT to determine the relationship of clinical and microbiologic outcomes to drug used, and to M. genitalium drug susceptibility. Projects will interact synergistically, and all will utilize the Biostatistics Core (James Hughes) and Laboratory Core (Walter Stamm). Sheila Lukehart proposes the STI TM CRC Developmental Awards Program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031448-15
Application #
6943430
Study Section
Special Emphasis Panel (ZAI1-NBS-M (M4))
Program Officer
Rogers, Elizabeth
Project Start
1997-07-01
Project End
2009-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
15
Fiscal Year
2005
Total Cost
$1,825,776
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
White, Darcy; Grey, Jeremy A; Gorbach, Pamina M et al. (2017) Racial Differences in Partnership Attributes, Typologies, and Risk Behaviors Among Men Who Have Sex With Men in Atlanta, Georgia. Arch Sex Behav 46:961-975
Kohler, Pamela K; Campos, Pablo E; Garcia, Patricia J et al. (2016) Sexually transmitted infection screening uptake and knowledge of sexually transmitted infection symptoms among female sex workers participating in a community randomised trial in Peru. Int J STD AIDS 27:402-10
Winer, Rachel L; Hughes, James P; Feng, Qinghua et al. (2016) Incident Detection of High-Risk Human Papillomavirus Infections in a Cohort of High-Risk Women Aged 25-65 Years. J Infect Dis 214:665-75
Kissinger, Patricia J; White, Scott; Manhart, Lisa E et al. (2016) Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. Sex Transm Dis 43:599-602
Khosropour, Christine M; Manhart, Lisa E; Gillespie, Catherine W et al. (2015) Efficacy of standard therapies against Ureaplasma species and persistence among men with non-gonococcal urethritis enrolled in a randomised controlled trial. Sex Transm Infect 91:308-13
Huang, Claire E; Cassels, Susan L; Winer, Rachel L (2015) Self-reported sex partner dates for use in measuring concurrent sexual partnerships: correspondence between two assessment methods. Arch Sex Behav 44:873-83
Khosropour, Christine M; Manhart, Lisa E; Colombara, Danny V et al. (2014) Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. Sex Transm Infect 90:3-7
Winer, Rachel L; Xi, Long Fu; Shen, Zhenping et al. (2014) Viral load and short-term natural history of type-specific oncogenic human papillomavirus infections in a high-risk cohort of midadult women. Int J Cancer 134:1889-98
Gillespie, Catherine W; Manhart, Lisa E; Lowens, M Sylvan et al. (2013) Asymptomatic urethritis is common and is associated with characteristics that suggest sexually transmitted etiology. Sex Transm Dis 40:271-4
Manhart, Lisa E; Khosropour, Christine M; Liu, Congzhu et al. (2013) Bacterial vaginosis-associated bacteria in men: association of Leptotrichia/Sneathia spp. with nongonococcal urethritis. Sex Transm Dis 40:944-9

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