This is a renewal application for the Midwest Sexually Transmitted Diseases Cooperative Research Center (STDCRC). It is a consortium agreement between Indiana University and Northwestern University Schools of Medicine. The primary objective of this Center is to focus the efforts of investigators with different scientific backgrounds and interests on sexually transmitted diseases in such a way as to lead to new approaches to primary and secondary prevention. Specifically, it is our intention to foster productive, interdisciplinary collaboration in such a way as to enhance the capabilities of individual investigators and to stimulate the entry of other talented investigators into the field. The projects proposed include two focused on diseases associated with genital ulcers, herpes simplex virus and Haemophilus ducreyi infection. The first of these will evaluate molecular mechanisms associated with infectivity and dissemination in a mouse model; while the second will standardize a human challenge model and use it to evaluate the cellular immune response to H. ducreyi. A third project is directed at understanding the role which antigenic variation in pili play in the pathogenesis of Neisseria gonorrhoeae infections; again, using a human challenge model in collaboration with the STDCRC in Chapel Hill, NC. Three projects focus on different aspects of human papillomavirus (HPV) infections. One of these is directed at the mechanisms by which the E7 gene product of high risk HPV contributes to the development of anogenital malignancies and the pathogenesis of infection. The second seeks to define the extent to which immunosuppression associated with transplantation or pregnancy results in reactivation and expression of latent HPV infection; while a third project is focused on the mechanisms by which gene expression and replication of HPV are regulated by silencer and other genetic elements. Consistent with the objective of primary prevention is a project which seeks to define the timing of recurrent sexually transmitted infections and their relationship to inter- and intra-personal factors which may modify the risk of recurrent infection. These seven projects will be supported by an Administrative Core, a Biostatistical Core, and a Clinical/Laboratory Core with the latter monitoring sexually transmitted diseases as biological markers for evidence of recurrent infection. This core will also collect specimens and data from individuals infected with the different sexually transmitted pathogens and distribute them, along with appropriate clinical data, to the various projects. The extensive collaboration and cross- disciplinary fertilization which exists among the different projects will be reinforced by frequent scientific/administrative meetings to assess progress of each project and provide constructive criticism and assistance.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (SRC (65))
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Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
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Hensel, Devon J; Nance, Jennifer; Fortenberry, J Dennis (2016) The Association Between Sexual Health and Physical, Mental, and Social Health in Adolescent Women. J Adolesc Health 59:416-21
Hensel, Devon J; Selby, Sarah; Tanner, Amanda E et al. (2016) A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women. Sex Transm Dis 43:531-6
Hensel, Devon J; Tanner, Amanda E; Sherrow, Ashley et al. (2016) A longitudinal daily diary analysis of condom use during bleeding-associated vaginal sex among adolescent females. Sex Transm Infect 92:337-9
Singer, Martin; Li, Wei; Morré, Servaas A et al. (2016) Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers. J Infect Dis 214:489-95
van Rensburg, Julia J; Lin, Huaiying; Gao, Xiang et al. (2015) The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection. MBio 6:e01315-15
Bell, David L; Rosenberger, Joshua G; Ott, Mary A (2015) Masculinity in adolescent males' early romantic and sexual heterosexual relationships. Am J Mens Health 9:201-8
Li, Zhuokai; Liu, Hai; Tu, Wanzhu (2015) A sexually transmitted infection screening algorithm based on semiparametric regression models. Stat Med 34:2844-57
Hensel, Devon J; Sorge, Brandon H (2014) Adolescent women's daily academic behaviors, sexual behaviors, and sexually related emotions. J Adolesc Health 55:845-7
Janowicz, Diane M; Zwickl, Beth W; Fortney, Kate R et al. (2014) Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection. BMC Microbiol 14:166
Best, Candace; Tanner, Amanda E; Hensel, Devon J et al. (2014) Young women's contraceptive microbicide preferences: associations with contraceptive behavior and sexual relationship characteristics. Perspect Sex Reprod Health 46:15-22

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