Abstract

The objective of this core is to provide diagnostic services, patient specimens and laboratory data in support of the projects within the center. The core is comprised of the director, the laboratory manager, and three research analysts. At each patient encounter, various specimens will be obtained and transported to the laboratory for testing, shipping and aliquot archiving. Specimens to be collected include vaginal swabs, urines, endocervical swabs, serum and lesion swabs. Among diagnostic assays that will be performed are polymerase chain reaction assays for C. trachomatis, N. gonorrhoeae, T. vaginalis and M. genitalium. In addition, vaginal swab specimens that contain C. trachomatis DNA will be processed for chlamydial strain genotyping by nucleotide sequencing of the omp1 gene, and for quantitative estimation of organism load by PCR. Fresh clinical isolates of herpes simplex virus types 1 and 2 will be obtained from subjects in the clinical core and provided to Dr. Spear for use in her mouse model of HSV genital infection. In addition, endocervical samples from women with and without N. gonorrhoeae infection will be provided for detection of gonococcal phospholipase D.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031494-16
Application #
7270410
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
16
Fiscal Year
2006
Total Cost
$115,573
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Hensel, Devon J; Nance, Jennifer; Fortenberry, J Dennis (2016) The Association Between Sexual Health and Physical, Mental, and Social Health in Adolescent Women. J Adolesc Health 59:416-21
Hensel, Devon J; Selby, Sarah; Tanner, Amanda E et al. (2016) A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women. Sex Transm Dis 43:531-6
Hensel, Devon J; Tanner, Amanda E; Sherrow, Ashley et al. (2016) A longitudinal daily diary analysis of condom use during bleeding-associated vaginal sex among adolescent females. Sex Transm Infect 92:337-9
Singer, Martin; Li, Wei; Morré, Servaas A et al. (2016) Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers. J Infect Dis 214:489-95
van Rensburg, Julia J; Lin, Huaiying; Gao, Xiang et al. (2015) The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection. MBio 6:e01315-15
Bell, David L; Rosenberger, Joshua G; Ott, Mary A (2015) Masculinity in adolescent males' early romantic and sexual heterosexual relationships. Am J Mens Health 9:201-8
Li, Zhuokai; Liu, Hai; Tu, Wanzhu (2015) A sexually transmitted infection screening algorithm based on semiparametric regression models. Stat Med 34:2844-57
Janowicz, Diane M; Zwickl, Beth W; Fortney, Kate R et al. (2014) Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection. BMC Microbiol 14:166
Best, Candace; Tanner, Amanda E; Hensel, Devon J et al. (2014) Young women's contraceptive microbicide preferences: associations with contraceptive behavior and sexual relationship characteristics. Perspect Sex Reprod Health 46:15-22
Batteiger, Byron E; Wan, Raymond; Williams, James A et al. (2014) Novel Chlamydia trachomatis strains in heterosexual sex partners, Indianapolis, Indiana, USA. Emerg Infect Dis 20:1841-7

Showing the most recent 10 out of 86 publications