The long-term objective of Project 3 is to characterize the natural history and developmental epidemiology of sexually transmitted infections (STI) among young men from middle to late adolescence and into young adulthood. The,specific aims are: (1) To describe adolescent men's patterns of infection by 5 sexually transmitted organisms (C. trachomatis trachomatis. Neisseria gonorrhoeae. Trichomonas vaginalis. Mycoplasma genitalium, Ureaplasma urealyticum, biovar 2), and non-gonococcal urethritis as a function of time;(2) To describe adolescent men's patterns of infection acquisition, organism shedding, symptom development, and pyuria for each target organism using event-contingent every other day samples for 14 days;And (3) To describe the psychological, interpersonal, social and behavioral phenomena associated with occurrence of sexual events using electronic cell phone diary reports among adolescent men. Through the Clinical Core, we will recruit 234 African American, Latino and Euro-American young men, ages 14-17 at enrollment, from a community with high STI prevalence. Participants will be followed for up to 57 months. In conjunction with the Laboratory Core, we will test monthly surveillance urine samples and more frequent event-contingent samples with PCR and cell counts to characterize the natural history ofthe above 5 STI and NGU across adolescence. Quarterly audio computer assisted self interviews (ACASI) will be used to characterize demographic, behavioral, biological, and socio-cultural correlates of STI acquisition and sequence. Daily cell phone diaries will be used to describe the psychological, interpersonal, and behavioral phenomena associated with specific sexual events and STI. The proposed research addressed three priorities related to STI: (1) A focus on adolescents, (2) The interactions among different organisms, including emerging pathogens such as M. genitalium and (3) the provision of key developmental epidemiology and behavioral data to inform interventions.

Public Health Relevance

Sexually transmitted infections (STI) are a signficant public health problem for adolescent men, with marked disparities by race and ethnicity. Prevention has been hampered by limited knowledge about the development of STI across adolescence. The purpose of this research is to longitudinally describe patterns of and risk factors for, acquisition of five STIs among multi-ethnic 14 to 17 year old young men.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-NBS-M (M4))
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Indiana University-Purdue University at Indianapolis
United States
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Hensel, Devon J; Nance, Jennifer; Fortenberry, J Dennis (2016) The Association Between Sexual Health and Physical, Mental, and Social Health in Adolescent Women. J Adolesc Health 59:416-21
Hensel, Devon J; Selby, Sarah; Tanner, Amanda E et al. (2016) A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women. Sex Transm Dis 43:531-6
Hensel, Devon J; Tanner, Amanda E; Sherrow, Ashley et al. (2016) A longitudinal daily diary analysis of condom use during bleeding-associated vaginal sex among adolescent females. Sex Transm Infect 92:337-9
Singer, Martin; Li, Wei; Morré, Servaas A et al. (2016) Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers. J Infect Dis 214:489-95
van Rensburg, Julia J; Lin, Huaiying; Gao, Xiang et al. (2015) The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection. MBio 6:e01315-15
Bell, David L; Rosenberger, Joshua G; Ott, Mary A (2015) Masculinity in adolescent males' early romantic and sexual heterosexual relationships. Am J Mens Health 9:201-8
Li, Zhuokai; Liu, Hai; Tu, Wanzhu (2015) A sexually transmitted infection screening algorithm based on semiparametric regression models. Stat Med 34:2844-57
Best, Candace; Tanner, Amanda E; Hensel, Devon J et al. (2014) Young women's contraceptive microbicide preferences: associations with contraceptive behavior and sexual relationship characteristics. Perspect Sex Reprod Health 46:15-22
Batteiger, Byron E; Wan, Raymond; Williams, James A et al. (2014) Novel Chlamydia trachomatis strains in heterosexual sex partners, Indianapolis, Indiana, USA. Emerg Infect Dis 20:1841-7
Hensel, Devon J; Sorge, Brandon H (2014) Adolescent women's daily academic behaviors, sexual behaviors, and sexually related emotions. J Adolesc Health 55:845-7

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