Abstract

The purpose of the Immunology Core is to serve the common technical and scientific needs of the component projects and to enhance scientific interchange and transfer of skills from American to PNG and Kenyan investigators. The major technical functions of the core are to provide the facilities and experienced technical assistant to perform standardized assays for detection of cytokine and antibody production by T and B lymphocytes and basophils. in addition, the core will produce and purify many of the monoclonal antibodies used in the assays which are not commercially available. A centralized location of these assays will help ensure standardization and quality control and aid in the technical refinement of the assays, especially for use in the field. A core laboratory will also facilitate establishment and maintenance of a bank of frozen serum, cryopreserved lymphocytes, and genomic DNA for use in subsequent studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI033061-09
Application #
6611107
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
9
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Nayakwadi Singer, Monica; Heath, Claire; Muinde, Jackson et al. (2017) Pneumococcal Vaccine Response After Exposure to Parasites in Utero, in Infancy, or Mid-Childhood. Pediatrics 139:
Pedraza-Sánchez, Sigifredo; Hise, Amy G; Ramachandra, Lakshmi et al. (2013) Reduced frequency of a CD14+ CD16+ monocyte subset with high Toll-like receptor 4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns. Clin Vaccine Immunol 20:962-71
Bowman, Natalie M; Kawai, Vivian; Gilman, Robert H et al. (2011) Autonomic dysfunction and risk factors associated with Trypanosoma cruzi infection among children in Arequipa, Peru. Am J Trop Med Hyg 84:85-90
Levy, Michael Z; Bowman, Natalie M; Kawai, Vivian et al. (2009) Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots. Clin Infect Dis 48:1104-6
Rao, Ramakrishna U; Huang, Yuefang; Bockarie, Moses J et al. (2009) A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA. Trans R Soc Trop Med Hyg 103:365-70
Michael, Edwin; Snow, Lucy C; Bockarie, Moses J (2009) Ecological meta-analysis of density-dependent processes in the transmission of lymphatic filariasis: survival of infected vectors. J Med Entomol 46:873-80
Bockarie, Moses J; Pedersen, Erling M; White, Graham B et al. (2009) Role of vector control in the global program to eliminate lymphatic filariasis. Annu Rev Entomol 54:469-87
Michael, Edwin; Malecela, Mwele N; Zervos, Mihail et al. (2008) Global eradication of lymphatic filariasis: the value of chronic disease control in parasite elimination programmes. PLoS One 3:e2936
Levy, Michael Z; Quispe-Machaca, Victor R; Ylla-Velasquez, Jose L et al. (2008) Impregnated netting slows infestation by Triatoma infestans. Am J Trop Med Hyg 79:528-34
Bowman, Natalie M; Kawai, Vivian; Levy, Michael Z et al. (2008) Chagas disease transmission in periurban communities of Arequipa, Peru. Clin Infect Dis 46:1822-8

Showing the most recent 10 out of 15 publications