The objective of this Demonstration and Education Project is to evaluate aspects of the education program for asthma among inner city children. The primary area that will be addressed is the control of allergens in apartments and houses. These studies address both the appropriate methods for allergen avoidance in this community and how this should be integrated into overall asthma care. The goals of this project are: a) A controlled trial of allergen avoidance among 95 school age children with asthma in Atlanta. The children are randomly assigned to three groups: Active avoidance measures; placebo avoidance measures; and a control group whose houses are only visited for a final assessment. The study is designed to evaluate the effects of mite and cockroach avoidance among low income families in a city where both of these allergens are associated with asthma. b) A trial of avoidance in 30 randomly selected children, in which aggressive avoidance measures will be- instituted knowing the specific sensitization of the children. c) Detailed studies of methods of measuring exposure; regimes for controlling cockroaches; and the relevance of room air cleaners in low income housing. Studies on cockroaches will evaluate methods of combining hydromethanon (Siegel and Combats) with abamectin (Avert), each used as bait. d) Design and implement asthma educational programs for a primary care clinic. The program will integrate specific allergen avoidance into asthma care and general health education. e) Establish a school based asthma education program for children who register with the school nurse. The objective is to reinforce education provided in the clinic and to develop a general health program for children with asthma.

Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
2000
Total Cost
$193,125
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Sun, Jie; Cardani, Amber; Sharma, Ashish K et al. (2011) Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PLoS Pathog 7:e1002173
Commins, Scott P; James, Hayley R; Kelly, Libby A et al. (2011) The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-?-1,3-galactose. J Allergy Clin Immunol 127:1286-93.e6
Stevens, Whitney W; Sun, Jie; Castillo, Jonathan P et al. (2009) Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease. Viral Immunol 22:243-51
Rönmark, Eva; Bjerg, Anders; Perzanowski, Matthew et al. (2009) Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J Allergy Clin Immunol 124:357-63, 63.e1-15
Commins, Scott P; Satinover, Shama M; Hosen, Jacob et al. (2009) Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol 123:426-33
Paget-Brown, A O; Hunt, J F; Gaston, B (2007) Tracheal aspirate pH is alkaline in pre-term human infants. Eur Respir J 30:840-2
Zaman, Khalequz; Hanigan, Marie H; Smith, Alison et al. (2006) Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol 34:387-93
Henderson, Edward M; Gaston, Benjamin (2005) SNOR and wheeze: the asthma enzyme? Trends Mol Med 11:481-4
Platts-Mills, T A; Rakes, G; Heymann, P W (2000) The relevance of allergen exposure to the development of asthma in childhood. J Allergy Clin Immunol 105:S503-8
Sporik, R; Squillace, S P; Ingram, J M et al. (1999) Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools. Thorax 54:675-80

Showing the most recent 10 out of 12 publications