Adolescents who have received care in Emergency Departments represent a group who do not regularly seek health care from facilities providing preventative reproductive health screening yet who have a high prevalence of asymptomatic and a unrecognized STDS. In this project urine LCR screening for Neisseria gonorrhoeae and Chlamydia trachomatis provided through outreach (as opposed to clinic-based) activity and guided by a social network informed screening protocols originating with infected individuals identified at the time of emergency room attendance will be studied.
The specific aims of this project are: 1) To define the prevalence of undetected N. gonorrhoeae and C. trachomatis in adolescents receiving care for reasons other than possible STD-related complaints at a large urban emergency room; 2) To characterize in an exploratory fashion, the health seeking behaviors, social (and sexual) networks, and other epidemiologic and behavioral characteristics of adolescents with and at risk for STDs attending the emergency room; 3) To conduct a randomized clinical trial comparing traditional health department partner notification activities to a social network-informed screening intervention for identifying and testing bacterial STDs using LCR tests; 4) To d4evelop, in partnership with our local health department, new strategies for identifying and treating STDs in a high prevalence community as well as opportunities for preventing future infection in adolescents identified through opportunistic screening performed at the time of emergency room attendance. Outcome measures will include descriptive analyses of reproductive health care seeking behaviors in adolescents seen in the emergency room, the prevalence of otherwise undetected bacterial STDs in adolescents seen in emergency room, and the numbers of infected persons identified through netowrk- informed outreach and screening per unit of Health Department Disease Int4rvention Activity time. The project has the potential to provide one of the most randomized clinical trials for evaluating traditional partner notification activities as compared to other outreach mechanisms for identifying individuals with and at risk for STDs, as well as providing a new strategy for STD intervention in adolescents, the group with highest STD morbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI038514-05
Application #
6212411
Study Section
Special Emphasis Panel (ZAI1-ALR-M (M1))
Project Start
1995-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Andres, Robert L; Zhao, Yuan; Klebanoff, Mark A et al. (2013) The impact of tobacco use on preterm premature rupture of the membranes. Am J Perinatol 30:185-90
Mastrobattista, Joan M; Klebanoff, Mark A; Carey, J Christopher et al. (2008) The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy. Am J Perinatol 25:233-7
Hendler, Israel; Andrews, William W; Carey, Christopher J et al. (2007) The relationship between resolution of asymptomatic bacterial vaginosis and spontaneous preterm birth in fetal fibronectin-positive women. Am J Obstet Gynecol 197:488.e1-5
Geisler, William M; Chyu, Laura; Kusunoki, Yasamin et al. (2006) Health insurance coverage, health care-seeking behaviors, and genital chlamydial infection prevalence in sexually active young adults. Sex Transm Dis 33:389-96
Sizemore Jr, James M; Lakeman, Fred; Whitley, Richard et al. (2006) The spectrum of genital herpes simplex virus infection in men attending a sexually transmitted disease clinic. J Infect Dis 193:905-11
Annang, Lucy; Grimley, Diane M; Hook 3rd, Edward W (2006) Vaginal douche practices among black women at risk: exploring douching prevalence, reasons for douching, and sexually transmitted disease infection. Sex Transm Dis 33:215-9
Andrews, William W; Klebanoff, Mark A; Thom, Elizabeth A et al. (2006) Midpregnancy genitourinary tract infection with Chlamydia trachomatis: association with subsequent preterm delivery in women with bacterial vaginosis and Trichomonas vaginalis. Am J Obstet Gynecol 194:493-500
Ross, Shannon A; Novak, Zdenek; Ashrith, Guha et al. (2005) Association between genital tract cytomegalovirus infection and bacterial vaginosis. J Infect Dis 192:1727-30
Geisler, William M; Yu, Shuying; Hook 3rd, Edward W (2005) Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: implications for diagnostic approach and management. Sex Transm Dis 32:630-4
Lichtenstein, Bronwen; Hook 3rd, Edward W; Sharma, Amit K (2005) Public tolerance, private pain: stigma and sexually transmitted infections in the American Deep South. Cult Health Sex 7:43-57

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