Core - Clinical Facility

Donegan, S P.

Abstract

Drs. Jan Paradise and Lydia Shrier will direct the Adolescent Clinical Core at the Boston Medical Center (BMC) and Children's Hospital that will enroll adolescents who will participate in behavioral intervention studies and provide clinical materials and epidemiologic information. Dr. David Soper will direct the STD and OB/GYN Clinical Cores at the Medical University of South Carolina, which will enroll subjects exposed to and/or infected with N. gonorrhoeae for studies on the importance of iron-regulated proteins in pathogenesis and immunity. Clinical specimen form subjects infected with N. gonorrhoeae will also be provided.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Program--Cooperative Agreements (U19)
• Project #: 5U19AI038515-07
• Application #: 6500984
• Project Start: 2001-09-01
• Project End: 2002-08-31
• Support Year: 7
• Fiscal Year: 2001

Institution

• Name: Boston Medical Center
• DUNS #: 005492160
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02118

Publications

Ketterer, Margaret R; Rice, Peter A; Gulati, Sunita et al. (2016) Desialylation of Neisseria gonorrhoeae Lipooligosaccharide by Cervicovaginal Microbiome Sialidases: The Potential for Enhancing Infectivity in Men. J Infect Dis 214:1621-1628

Agarwal, Sarika; Sebastian, Shite; Szmigielski, Borys et al. (2008) Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J Bacteriol 190:3129-39

Sagar, Manish; Wu, Xueling; Lee, Sandra et al. (2006) Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol 80:9586-98

Shen, Li; Feng, Xiaogeng; Yuan, Yuan et al. (2006) Selective promoter recognition by chlamydial sigma28 holoenzyme. J Bacteriol 188:7364-77

Sagar, Manish; Kirkegaard, Erin; Lavreys, Ludo et al. (2006) Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses 22:430-7

Wu, Hsing-Ju; Seib, Kate L; Srikhanta, Yogitha N et al. (2006) PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae. Mol Microbiol 60:401-16

Seib, Kate L; Wu, Hsing-Ju; Kidd, Stephen P et al. (2006) Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment. Microbiol Mol Biol Rev 70:344-61

Porter, Edith; Yang, Huixia; Yavagal, Sujata et al. (2005) Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 73:4823-33

Wu, Hsing-Ju; Seib, Kate L; Edwards, Jennifer L et al. (2005) Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells. Infect Immun 73:8444-8

Seib, Kate L; Simons, Mark P; Wu, Hsing-Ju et al. (2005) Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay. Infect Immun 73:5269-72