Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI040038-01
Application #
2076978
Study Section
Special Emphasis Panel (ZAI1-SCO-M (85))
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Liu, Helene Minyi; Aizaki, Hideki; Machida, Keigo et al. (2012) Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One 7:e43600
Machida, Keigo; McNamara, George; Cheng, Kevin T-H et al. (2010) Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol 185:6985-98
Machida, Keigo; Tsukamoto, Hidekazu; Mkrtchyan, Hasmik et al. (2009) Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A 106:1548-53
Machida, Keigo; Liu, Jian-Chang; McNamara, George et al. (2009) Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway. J Virol 83:12590-600
Machida, Keigo; Kondo, Yasuteru; Huang, Jeffrey Y et al. (2008) Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. J Virol 82:6711-20
Lai, Chao-Kuen; Jeng, King-Song; Machida, Keigo et al. (2008) Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology 370:295-309
Aswad, Fred; Dennert, Gunther (2006) P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes. Cell Immunol 243:58-65
Kawamura, Hiroki; Aswad, Fred; Minagawa, Masahiro et al. (2006) P2X7 receptors regulate NKT cells in autoimmune hepatitis. J Immunol 176:2152-60
Machida, Keigo; Cheng, Kevin T-H; Lai, Chao-Kuen et al. (2006) Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol 80:7199-207
Dennert, Gunther; Aswad, Fred (2006) The role of NKT cells in animal models of autoimmune hepatitis. Crit Rev Immunol 26:453-73

Showing the most recent 10 out of 51 publications