The """"""""Safeguard the household"""""""" applicant partners have considerable expertise in training researchers, clinicians and laboratory scientists in aspects of HIV research. Many of these programs that are already in place can be used as models for expanding into the areas of treatment, prevention, laboratory and TB/OIs training and mentoring. New models will be set up for the fast and effective information dissemination of successful programmes, research models, and research results. Research and capacity is largely built through individuals participating in the research process, and the training core program will link training to the five project areas of this application, so that training and research will mutually reinforce each other.
The aims of the training core are: To build capacity in biomedical and behavioral science to conduct relevant, high quality, cutting edge research in the field of HIV prevention and treatment, TB/OI, and laboratory development, appropriate to the needs of the country. To develop a comprehensive training program, including diagnosis and clinical management for HIV/AIDS OI's and laboratory skills for South Africa which includes training in state-of-the-art scientific methods, including testing hypotheses, designing valid studies and analyzing data and training in the responsible conduct of research, which will support the four project areas of this collaboration. To recruit promising young South African scientists, particularly those from previously disadvantaged groups, and develop their research potential through advanced training and mentoring with established clinical, epidemiological and laboratory investigators from South Africa, the US or international agencies and institutions. To establish long-term co-operative relationships between South African and US research training institutions, including the Fogarty AITRP program, to support the training agenda. To support a two-way process of information dissemination between researchers, policy makers and program managers, which will ensure that the research needs of the country are determined collaboratively, and that research findings are translated into policy and practice efficiently and effectively. To undertake continuous evaluation of the training needs for staff at all levels; develop training plans; co-ordinate training and mentoring programs; and evaluate the effectiveness of training programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI053217-01
Application #
6594382
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Witwaterstrand
Department
Type
DUNS #
City
Johannesburg
State
Country
South Africa
Zip Code
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Toich, Jadrana T F; Taylor, Paul A; Holmes, Martha J et al. (2017) Functional Connectivity Alterations between Networks and Associations with Infant Immune Health within Networks in HIV Infected Children on Early Treatment: A Study at 7 Years. Front Hum Neurosci 11:635
Jankiewicz, Marcin; Holmes, Martha J; Taylor, Paul A et al. (2017) White Matter Abnormalities in Children with HIV Infection and Exposure. Front Neuroanat 11:88
Lewis, Joanna; Payne, Helen; Walker, A Sarah et al. (2017) Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial. Front Immunol 8:1162
Innes, Steve; van Toorn, Ronald; Otwombe, Kennedy et al. (2017) Late-Onset Hiv Encephalopathy In Children With Long-Standing Virologic Suppression Followed By Slow Spontaneous Recovery Despite no Change In Antiretroviral Therapy: 4 Case Reports. Pediatr Infect Dis J 36:e264-e267
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Ackermann, C; Andronikou, S; Saleh, M G et al. (2016) Early Antiretroviral Therapy in HIV-Infected Children Is Associated with Diffuse White Matter Structural Abnormality and Corpus Callosum Sparing. AJNR Am J Neuroradiol 37:2363-2369
van Zyl, Gert U; Bedison, Margaret A; van Rensburg, Anita Janse et al. (2015) Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells. J Infect Dis 212:39-43
Madhi, Shabir A; Izu, Alane; Nunes, Marta C et al. (2015) Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine. Vaccine 33:2662-9
Alhamud, A; Taylor, Paul A; Laughton, Barbara et al. (2015) Motion artifact reduction in pediatric diffusion tensor imaging using fast prospective correction. J Magn Reson Imaging 41:1353-64

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