Our proposal for a Center for Translational Research in Human Immunology and Biodefense gathersinvestigators from different backgrounds, yet unified through their interest in the biology of Dendritic Cells.As we planned this Center, we identified experts that we thought would synergize to provide the best possibleprogram on the topic of Human Dendritic Cells and in vivo Immunity to Biothreat.This Center is expected to be an integral component of the larger Network of Centers that areexpected to contribute complementary expertise. Thus, the Network Centers' expertise should broadlyencompass the fields of Human Immunology and Biodefense.Given the breadth of the topic, we should expect to identify gaps in the repertoire of collectiveexpertise. It will be the objective of these Pilot Projects to fill these knowledge gaps and to expand thediscoveries made in the Center. In doing so, we are hoping to attract to the field of Human Immunologyinvestigators who have proven to be outstanding contributors to Basic Immunology and possibly to otherfields as it applies to Technology Development.The five years of the Center Cycle will permit us to support up to ten Pilot Projects. These projectswill be financed for up to two years. Though the Center's Director is ultimately responsible for the proper useof the Center's resources, the Center's Steering Committee will play a critical role in the initiation andfollow-up of each of these Pilot Projects. It is proposed that each Pilot Project will be overseen/chaperoned,from inception to completion, by two of the Center's Investigators.
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