Abstract

Core B Reference Laboratory for LF Elimination This scientific core aims to establish a reference laboratory at Ain Shams University in Egypt for monitoring filariasis elimination programs. This will be a prototype for a network of regional reference laboratories that will have high throughput capability for parasite DNA detection and antibody testing to service monitoring needs of LF elimination programs in countries and regions. The Core will serve both Projects in the ICIDR. The Core is necessary for the large number of samples that will be collected in ICIDR. Project I, and it will also serve the needs of Project 2 (new tool development). We will upgrade laboratory capabilities with new instrumentation and training. The Core will receive, process, and archive samples. It will perform assays and report results to the Data Management Core and Project scientists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI065715-04
Application #
7626435
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$24,453
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Rao, Ramakrishna U; Nagodavithana, Kumara C; Samarasekera, Sandhya D et al. (2014) A comprehensive assessment of lymphatic filariasis inSri Lanka six years after cessation of mass drug administration. PLoS Negl Trop Dis 8:e3281
Abd Elaziz, Khaled M; El-Setouhy, Maged; Bradley, Mark H et al. (2013) Knowledge and practice related to compliance with mass drug administration during the Egyptian national filariasis elimination program. Am J Trop Med Hyg 89:260-4
Weil, Gary J; Curtis, Kurt C; Fischer, Peter U et al. (2011) A multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant Brugia malayi antigen Bm-14. Acta Trop 120 Suppl 1:S19-22
Laney, Sandra J; Ramzy, Reda M R; Helmy, Hanan H et al. (2010) Detection of Wuchereria bancrofti L3 larvae in mosquitoes: a reverse transcriptase PCR assay evaluating infection and infectivity. PLoS Negl Trop Dis 4:e602
Rao, Ramakrishna U; Huang, Yuefang; Bockarie, Moses J et al. (2009) A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA. Trans R Soc Trop Med Hyg 103:365-70
Laney, Sandra J; Buttaro, Caitlin J; Visconti, Sabato et al. (2008) A reverse transcriptase-PCR assay for detecting filarial infective larvae in mosquitoes. PLoS Negl Trop Dis 2:e251
Weil, Gary J; Kastens, Will; Susapu, Melinda et al. (2008) The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea. PLoS Negl Trop Dis 2:e344
Fischer, Peter; Erickson, Sara M; Fischer, Kerstin et al. (2007) Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis. Am J Trop Med Hyg 76:502-7
Farid, Hoda A; Morsy, Zakariya S; Helmy, Hanan et al. (2007) A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. Am J Trop Med Hyg 77:593-600
El-Setouhy, Maged; Abd Elaziz, Khaled M; Helmy, Hanan et al. (2007) The effect of compliance on the impact of mass drug administration for elimination of lymphatic filariasis in Egypt. Am J Trop Med Hyg 77:1069-73

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