Abstract

The Broad Institute of Harvard and MIT is an industrial-scale genome center, with large economies of scale that allow us to provide genbtyping services at very competitive prices. This group of scientists comprising the Genotyping Core will: (1) Produce approximately 15.5 million genotypes in years 1 and 2 of this project. i (2) Collaborate on data analysis including defining all associations with the specific aim of defining associations between human leukocyte antigen (HLA) region genes or genetic markers and immune-mediated diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067152-05
Application #
7778318
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
5
Fiscal Year
2009
Total Cost
$618,192
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Pappas, D J; Lizee, A; Paunic, V et al. (2018) Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest. Pharmacogenomics J 18:367-376
Bronson, Paola G; Chang, Diana; Bhangale, Tushar et al. (2016) Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency. Nat Genet 48:1425-1429
Hauser, Stephen L (2015) The Charcot Lecture | beating MS: a story of B cells, with twists and turns. Mult Scler 21:8-21
Goyette, Philippe; Boucher, Gabrielle; Mallon, Dermot et al. (2015) High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet 47:172-9
Morris, D L; Fernando, M M A; Taylor, K E et al. (2014) MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun 15:210-7
Gourraud, Pierre-Antoine; Khankhanian, Pouya; Cereb, Nezih et al. (2014) HLA diversity in the 1000 genomes dataset. PLoS One 9:e97282
Gourraud, Pierre-Antoine; Hollenbach, Jill A; Barnetche, Thomas et al. (2012) Standard methods for the management of immunogenetic data. Methods Mol Biol 882:197-213
Gourraud, Pierre-Antoine; Gilson, Leena; Girard, Mathilde et al. (2012) The role of human leukocyte antigen matching in the development of multiethnic ""haplobank"" of induced pluripotent stem cell lines. Stem Cells 30:180-6
Morris, David L; Taylor, Kimberly E; Fernando, Michelle M A et al. (2012) Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet 91:778-93
Mack, Steven J; Gourraud, Pierre-Antoine; Single, Richard M et al. (2012) Analytical methods for immunogenetic population data. Methods Mol Biol 882:215-44

Showing the most recent 10 out of 57 publications