The purpose of the Mouse Biology and Stem Cell Core is to provide a wide range of murine-based assays for investigators from Project 1-3.
Specific aims i nclude (1) evaluation of normal mice and genetic (mutant) strains for LD50 (survival) after radiation, tissue pathology, hematopoietic cell culture, and chromose breakage (2) evaluation of IF profiles (signature profiles) (3) evaluation of biodosimetry in mice and (4) evaluation of candidate radioprotective agents in mice. Based on preclinical data in the mouse model, we will determine suitable radioprotective agents for further study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067751-03
Application #
7493029
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
3
Fiscal Year
2007
Total Cost
$332,541
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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