We have developed a three-part program designed to recruit more investigators into the area of radiobiology research and more specifically exploring medical countermeasures to radiation exposure. Recruiting post residency medical doctors into radiobiology research in a mentored laboratory setting. Providing established Investigators opportunities to acquire new skills relevant to radiobiology research through a mini-sabbatical program. Promoting continuing education in the biomedical scientific field community in areas of radiation and early response and radiobiology research. There exists the need to increase the numbers of researchers developing new products or regimens which mitigate and /or treat radiation post exposure, products which protect against radiation pre-exposure, high throughput diagnostic systems to rapid assess levels and types of radiation exposure, improved antibiotic and antiviral regimens to control post-exposure infection in the context of immunosuppression and trauma. Our program will serve as a catalyst to encourage some of the brightest and most talented clinical scientists in the country to transition into the area of radiobiology research. The Dana-Farber Cancer Institute and Harvard University campus offers a wealth of research facilities, faculty and resources combined with their outstanding affiliate institutions and laboratories offer unlimited opportunities to acquire new skills and participate in beneficial scientific collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067751-05
Application #
7923842
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$102,178
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Beemelmanns, Christine; Ramadhar, Timothy R; Kim, Ki Hyun et al. (2017) Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett 19:1000-1003
Guinan, Eva C; Palmer, Christine D; Mancuso, Christy J et al. (2014) Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. Innate Immun 20:697-711
Guinan, Eva C; Barbon, Christine M; Kalish, Leslie A et al. (2011) Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med 3:110ra118
D'Andrea, Alan D (2010) Susceptibility pathways in Fanconi's anemia and breast cancer. N Engl J Med 362:1909-19
Parmar, Kalindi; Kim, Jungmin; Sykes, Stephen M et al. (2010) Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells 28:1186-95
Tolopko, Andrew N; Sullivan, John P; Erickson, Sean D et al. (2010) Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities. BMC Bioinformatics 11:260
Sun, Yingli; Jiang, Xiaofeng; Xu, Ye et al. (2009) Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol 11:1376-82
Moldovan, George-Lucian; D'Andrea, Alan D (2009) FANCD2 hurdles the DNA interstrand crosslink. Cell 139:1222-4
Kim, Jung Min; Parmar, Kalindi; Huang, Min et al. (2009) Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell 16:314-20
Kim, Kwanghee; Pollard, Julianne M; Norris, Andrew J et al. (2009) High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res 15:7238-45

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