Abstract

The overall objectives of the program are to develop biodosimetry and effective countermeasures for radiation exposure. All projects will require access to different radiation sources. The Radiation Resource Core will provide dosimetry, radiobiology support, as well as access to different types of radiation sources including both low and high LET radiations. The Core will be responsible for advising on appropriate radiation sources to use and will coordinate irradiation protocols. The Core will directly supervise any gamma-ray exposures that use the J.L. Shepherd Model 81-14A Cs-137 irradiator. This irradiator has the capability of providing both whole body and partial body exposures of small animals. The Core will also oversee the irradiations with the Varian CLINAC 4 at the Fred Hutchinson Cancer Research Center and will provide access to alpha radiation. The alpha source will, be At-211, which is generated in the medical cyclotron in the Department of Radiation Oncology at the University of Washington.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067770-05
Application #
7930695
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
2012-07-31
Budget Start
2009-08-01
Budget End
2012-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$130,852
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Nielsen, Christopher E; Wang, Xihai; Robinson, Robert J et al. (2014) Carcinogenic and inflammatory effects of plutonium-nitrate retention in an exposed nuclear worker and beagle dogs. Int J Radiat Biol 90:60-70
Venkataraman, G M; Geraghty, D; Fox, J et al. (2013) Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease. Tissue Antigens 81:204-11
Leko, Vid; Varnum-Finney, Barbara; Li, Hongzhe et al. (2012) SIRT1 is dispensable for function of hematopoietic stem cells in adult mice. Blood 119:1856-60
Nielsen, Christopher E; Wilson, Dulaney A; Brooks, Antone L et al. (2012) Microdistribution and long-term retention of 239Pu (NO3)4 in the respiratory tracts of an acutely exposed plutonium worker and experimental beagle dogs. Cancer Res 72:5529-36
Pogosova-Agadjanyan, Era L; Fan, Wenhong; Georges, George E et al. (2011) Identification of radiation-induced expression changes in nonimmortalized human T cells. Radiat Res 175:172-84
Ivey, Richard G; Moore, Heather D; Voytovich, Uliana J et al. (2011) Blood-based detection of radiation exposure in humans based on novel phospho-Smc1 ELISA. Radiat Res 175:266-81
Mielcarek, Marco; Storb, Rainer; Georges, George E et al. (2011) Mesenchymal stromal cells fail to prevent acute graft-versus-host disease and graft rejection after dog leukocyte antigen-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant 17:214-25
Graves, Scott S; Stone, Diane M; Loretz, Carol et al. (2011) Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantation. Transplantation 91:833-40
Wilson, Dulaney A; Brigantic, Andrea; Morgan, William F (2011) The association of inbreeding with lung fibrosis incidence in Beagle dogs that inhaled 238PuO2 or 239PuO2. Radiat Res 176:781-6
Lee, Won Sik; Suzuki, Yasuhiro; Graves, Scott S et al. (2011) Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant 17:465-75

Showing the most recent 10 out of 26 publications