This U19 consortium grant is an interdisciplinary, multi-investigator research program that requires a well- organized, and efficient Administrative Core to ensure its success. Dr. Chao will serve as the primary leader of the Administrative Core. He will assisted by Dr. David Kirsch who will act as the core co-leader. The overall goal for this core is to create and implement administrative and leadership mechanisms. These mechanisms will foster effective interactions amongst the program investigators to ensure a productive research effort and to ensure proper regulatory, financial and reporting standards. To accomplish our goal, the administrative core will be responsible for the overall organization, management, decision-making, communications, and periodic evaluations within the program. The administrative core will be responsible for data sharing oversight, protection of intellectual property, and involvement of institutional resources. This Core will also organize and support the activities of the internal steering committee and the External Scientific Advisory Committee.
The specific aims for the administrative core are:
Aim 1 : Provide overall strategic leadership and direction that affords opportunities for collaboration.
Aim 2 : Ensure maintenance of scientific rigor and milestones of project and core.
Aim 3 : Provide financial management for each project and core.
Aim 4 : Manage internal and external communications for the program.
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|Farris, Michael; McTyre, Emory R; Okoukoni, Catherine et al. (2018) Cortical Thinning and Structural Bone Changes in Non-Human Primates after Single-Fraction Whole-Chest Irradiation. Radiat Res 190:63-71|
|Naqvi, Ibtehaj; Gunaratne, Ruwan; McDade, Jessica E et al. (2018) Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. Mol Ther 26:1020-1031|
|Ghandhi, Shanaz A; Turner, Helen C; Shuryak, Igor et al. (2018) Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLoS One 13:e0191402|
|Castle, Katherine D; Daniel, Andrea R; Moding, Everett J et al. (2018) Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. Radiat Res 189:627-633|
|Andrews, Rachel N; Metheny-Barlow, Linda J; Peiffer, Ann M et al. (2017) Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res 187:599-611|
|Chen, Liang; Wilson, Justin E; Koenigsknecht, Mark J et al. (2017) NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nat Immunol 18:541-551|
|Fanning, K M; Pfisterer, B; Davis, A T et al. (2017) Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling. Am J Physiol Regul Integr Comp Physiol 313:R290-R297|
|Swanson, Karen V; Junkins, Robert D; Kurkjian, Cathryn J et al. (2017) A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med 214:3611-3626|
|Kurkjian, Cathryn J; Guo, Hao; Montgomery, Nathan D et al. (2017) The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. Sci Rep 7:17355|
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