Radiation Countermeasures Center of Research Excellence Core 3: Primate Studies Abstract The Primate Studies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates (NHP), following the specific priorities of the RadCCORE consortium and sharing tissue and data with other CMCRs nationwide. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include study planning, regulatory approvals, acquisition and maintenance of specific- pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data sharing and interaction with the biostatistics core to facilitate analysis and publication of findings. The main core user for the proposed funding period will be Project 3, FSL-1 as a GI and hematopoietic mitigator, but all Projects will be served, through sharing of tissues, fluids and data; design and review of plans for future prospective studies.

Public Health Relevance

Radiation Countermeasures Center of Research Excellence Core 3: Primate Studies Narrative The Primate Studies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates (NHP), following the specific priorities of the RadCCORE consortium and sharing tissue and data with other CMCRs nationwide. Core investigators have substantial experience and expertise studying radiation countermeasures in NHPs. The main core user will be Project 3, FSL-1 as a GI and hematopoietic mitigator, but all Projects will be served.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI067798-16
Application #
9940005
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
16
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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