The five original objectives of this Group provide high quality comprehensive mathematical biology and computational support to CHAVI.
Aim 1 is to develop novel methods for analysis of neutralizing antibody data.
Aim 2 is to develop phylogenetic tools for defining sequence correlates of biological characteristics.
Aim 3 is to support the structural biology program of CHAVI, the CHAVI B cell immunology and the vaccine design discovery teams.
Aim 4 is to provide the CHAVI sequence database analysis and support for all components of CHAVI.
Aim 5 will provide CTL peptide design for the T cell program.
Aim 6 was added in year two, and Alan Perelson was brought into the program to lead a mathematical modeling component of the project, to model primary infection, the immune response to infection, and the impact of vaccines
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