The Administrative, Subject Recruitment, and Sample Coordination Core under Dr Nel's leadership provides? for three key functions that cut across all the projects in this Center. The adminsitrative aspects of this Core? are the integration of activities between the various projects in the Center including animal use approvals,? human subject approvals and biohazard/chemical use and disposal functions. These activities are required? across all the projects in the Center. The administrative function also manages the finanacial obligations of? the Center within UCLA and the necessary sub-contracting arrangments with the University of Southern? California for their particiaption in the Ambient Particle Collection and Fractionation Core. The subject? coordination part of this core provides an absolutely critical function for the entire Center by identifying and? providing a pipeline of potential sujects for the human studies that are proposed in two of the three projects.? This involves both identifying and assisting in the screening of challenge study subjects for treatments in Dr.? Saxon and Riedl's project and identification of subjects for studies of various particulate challenge outcomes? related to Dr. Diaz-Sanchez's project. As human related subject activities or specimens will be handled to? one degree or another in each of the three projects in this Center; all projects are thus dependent upon this? core for a pipeline of potential subjects and human samples. The subject coordinator from the administrative? core provides for scheduling between the three projects so that it is possible for staff in various projects to? efficiently process and then assess different samples on the same subject's challenge materials. This is very? important as it requires several laboratories be brought into the scheduling of subjects so that personnel in? each laboratory are prepared to handle the smaples, (e.g. lavage proteins, PBMC, fluids, RNA) at the right? time. For generally every in vivo human study, two and often all the three Center projects will be? participating in analysis of the human derived materials. Finally, personnel in this core will organize? interdisciplinary activities, meetings and review of the Center by the UCLA board and external consultant, be? in charge of the yearly renewals and particularly be sure that all of the special University requirements of the? Center, e.g. overall administrative approval for all human and animal studies is completed in a timely fashion.?

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-SV-I (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Heber, David; Li, Zhaoping; Garcia-Lloret, Maria et al. (2014) Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct 5:35-41
Li, Ning; Wang, Meiying; Barajas, Berenice et al. (2013) Nrf2 deficiency in dendritic cells enhances the adjuvant effect of ambient ultrafine particles on allergic sensitization. J Innate Immun 5:543-54
Ooi, Aik T; Ram, Sonal; Kuo, Alan et al. (2012) Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. Am J Transl Res 4:219-28
Li, Ning; Nel, Andre E (2011) Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research. J Occup Environ Med 53:S74-9
Li, Ning; Harkema, Jack R; Lewandowski, Ryan P et al. (2010) Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares. Am J Physiol Lung Cell Mol Physiol 299:L374-83
Kang, Xuedong; Li, Ning; Wang, Meiying et al. (2010) Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid. Proteomics 10:520-31
George, Saji; Pokhrel, Suman; Xia, Tian et al. (2010) Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano 4:15-29
Tachdjian, Raffi; Al Khatib, Shadi; Schwinglshackl, Andreas et al. (2010) In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol 125:1128-1136.e8
Kovochich, Michael; Espinasse, Benjamin; Auffan, Melanie et al. (2009) Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. Environ Sci Technol 43:6378-84
Nel, Andre E; M├Ądler, Lutz; Velegol, Darrell et al. (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543-57

Showing the most recent 10 out of 30 publications