The proposed Project includes a complex interplay of both microbicide product development with threeclasses of novel microbicide candidates, as well as microbicide science advancement in which the threeclasses of active microbicides will be utilized as tools to better understand how an effective microbicide mustact. The product development components consist of three classes of compounds with well documentedmicrobicide potential that may be developed as single or combination agents utilizing gels and/or intravaginalrings that will allow long lasting microbicides to be developed and deployed. We believe the potentialadvancements in product development (new agents, long lasting delivery technology) and microbicidescience (pharmacodynamics, in vitro and ex vivo modeling, effects of seminal and vaginal fluids,acceptability testing methods for long lasting and combination products) make this proposal both inherentlynovel and important to the field of microbicide science in regard to the development of the next generation ofmicrobicide products. In whole, the Project also provides a new model for the performance of Core functionsby adding important assay development objectives to improve the ability to effectively prioritize microbicidedevelopment.The Administrative Core will play a critical and essential role in ensuring the smooth integration of thevarious Projects and Cores included in this cooperative agreement research program. The successfulperformance of this Project requires a high degree of communication and interaction between the variousProjects, the Cores, and the Corporate Partner. The Administrative Core will be responsible for managingand enhancing this constructive and synergistic interplay between the participating scientific groups.
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