The Administrative Core (Core A), which includes administrative, data management and virology components, will play an important role in ensuring the smooth integration of the four scientific projects and two cores included in this cooperative agreement grant application. The specific duties of the administrative core include: (a) administrative oversight and scientific leadership for each of the projects, assuring integration of individual components into the overall project, (b) coordination of the research projects and cores in order that they successfully collaborate and complete their specific aims, (c) the provision of fiscal oversight related to the budgetary interactions between the University of Pittsburgh, Pittsburgh, PA, and the University of Central Florida in Orlando, FL, Tulane University, Covington, LA and Auritec Pharmaceuticals in Pasadena, CA. The Administrative Core will also be responsible for the monitoring and evaluation of expenditures at each of the participant institutions and authorizing deviations from the written budget proposed in this grant, (d) facilitating the interaction with NIH program staff relating to the goals of this U19 grant in the development of combination topical microbicides, preparing the annual progress report for the program, (e) planning, scheduling and coordinating monthly conference calls and meetings for the Scientific Steering Committee comprised of selected scientists, NIH program staff and the key personnel from this U19 grant, and (f) planning, scheduling, and convening an annual meeting with the Scientific Advisory Panel (SAP) and the NIH Program Officer. The activities of the U19 grant will be summarized and presented to members of the SAP and to the NIH Program Officer. The Administrative Core will work with the SAP, to review and address their recommendation, and forward a final report to the SAP and NIH program officials, (g) provide virologic support for all 4 projects to ensure that the various data sets from each project are compatible to each other, and (h) coordinate the provision of biostatistical consulting services to all projects and data management for all scientific projects and cores.
Administrative is core is essential for fiscal and administrative oversight of the U19 program. Such an administrative oversight will provide high degree of iteration required between the laboratory projects and the formulations core and animal studies.
|Gong, Tiantian; Zhang, Wei; Parniak, Michael A et al. (2017) Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. J Pharm Innov 12:142-154|
|Eade, Colleen R; Diaz, Camila; Chen, Sixue et al. (2015) HIV-Enhancing Factors Are Secreted by Reproductive Epithelia upon Inoculation with Bacterial Vaginosis-Associated Bacteria. Protein Pept Lett 22:672-80|
|Wood, Matthew P; Cole, Amy L; Eade, Colleen R et al. (2014) The HIV-1 gp41 ectodomain is cleaved by matriptase to produce a chemotactic peptide that acts through FPR2. Immunology 142:474-83|
|Wood, Matthew P; Cole, Amy L; Ruchala, Piotr et al. (2013) A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion. PLoS One 8:e55478|
|Eade, Colleen R; Cole, Amy L; Diaz, Camila et al. (2013) The anti-HIV microbicide candidate RC-101 inhibits pathogenic vaginal bacteria without harming endogenous flora or mucosa. Am J Reprod Immunol 69:150-8|
|Eade, Colleen R; Diaz, Camila; Wood, Matthew P et al. (2012) Identification and characterization of bacterial vaginosis-associated pathogens using a comprehensive cervical-vaginal epithelial coculture assay. PLoS One 7:e50106|
|Levinson, Pauline; Choi, Robert Y; Cole, Amy L et al. (2012) HIV-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in HIV-serodiscordant relationships. PLoS One 7:e31996|
|Eade, Colleen R; Wood, Matthew P; Cole, Alexander M (2012) Mechanisms and modifications of naturally occurring host defense peptides for anti-HIV microbicide development. Curr HIV Res 10:61-72|
|Rinehart, Matthew T; Drake, Tyler K; Robles, Francisco E et al. (2011) Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy. J Biomed Opt 16:120510|
|Penberthy, W Todd; Chari, Soumya; Cole, Amy L et al. (2011) Retrocyclins and their activity against HIV-1. Cell Mol Life Sci 68:2231-42|
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