The Administrative Core will provide management and leadership to the Oklahoma Autoimmunity Center of Excellence (Oklahoma ACE) allowing for expedited translation of basic science advances into clinical application in the diagnosis and treatment of systemic autoimmune disease. In support of this goal, the Administrative Core will serve as the centralized coordinating resource for the ACE. Based upon its previous success, the Oklahoma ACE will continue to host a weekly Autoimmunity Forum, bringing together the 14 basic scientists and 12 clinical investigators, representing a number of different clinical specialties and complementary research areas, who serve as part of the Oklahoma ACE, as well as their trainees and other interested parties. We will also continue to invite ACE investigators from the rest of the ACE network to help forge and facilitate inter-ACE collaborations^ To accomplish these goals, the Administrative Core will focus on the following Services: 1) provide central management for the Oklahoma ACE components and activities; 2) facilitate interactions of the Oklahoma ACE with the ACE Network and the NIH ACE Program;3) promote multidisciplinary approaches to research;and 4) promote data sharing strategies. The Core Leader will facilitate communication among the ACE community, ensure compliance with all NIH policies, and provide a foundation for scientific growth in translational and basic research. The Administrative Core Leader will oversee all administrative and personnel issues, work with ACE investigators to resolve issues, review project progress, and assist in grant applications and publications developed by ACE investigators. The Core Leader will attend ACE Steering Committee meetings and be the primary contact for the NIH ACE Program. The Core Leader and administrative staff will be responsible for preparing and submitting all annual progress reports and just-in-time and other information as needed to the NIH. Through the assistance ofthe OMRF grants accounting office, the Core Leader and administrative staff will also be responsible for managing the Oklahoma ACE budget. The Administrative Core services will optimize the use of funding and ensure that the Oklahoma ACE goals are met in a timely manner.

Public Health Relevance

The Oklahoma ACE is comprised of a multidisciplinary team of physician scientists and basic science investigators with the common goal of improving autoimmune disease patient care through expediting the translation of basic science findings into clinical applications. The Administrative Core will provide the, Oklahoma ACE with centralized leadership and management.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oklahoma Medical Research Foundation
Oklahoma City
United States
Zip Code
St Clair, E William; Baer, Alan N; Wei, Chungwen et al. (2018) Clinical Efficacy and Safety of Baminercept, a Lymphotoxin ? Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol 70:1470-1480
Koelsch, Kristi A; Cavett, Joshua; Smith, Kenneth et al. (2018) Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sjögren's Syndrome. Arthritis Rheumatol 70:1102-1113
Hinks, Anne; Marion, Miranda C; Cobb, Joanna et al. (2018) Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. Arthritis Rheumatol 70:957-962
Pelikan, Richard C; Kelly, Jennifer A; Fu, Yao et al. (2018) Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks. Nat Commun 9:2905
Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Kheir, Joseph M; Guthridge, Carla J; Johnston, Jonathon R et al. (2018) Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus. Lupus Sci Med 5:e000247
Young, K A; Munroe, M E; Harley, J B et al. (2018) Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. Lupus 27:1524-1531
Jog, Neelakshi R; Chakravarty, Eliza F; Guthridge, Joel M et al. (2018) Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes. Front Immunol 9:2198
Fu, Yao; Tessneer, Kandice L; Li, Chuang et al. (2018) From association to mechanism in complex disease genetics: the role of the 3D genome. Arthritis Res Ther 20:216
Hanscombe, Ken B; Morris, David L; Noble, Janelle A et al. (2018) Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet 27:3813-3824

Showing the most recent 10 out of 133 publications