The proposed U19 program involves investigators at five different locations (Baylor Institute for Immunology Research, Dallas, TX;Nationwide Children's Hospital, Columbus, OH;Dynavax Technologies, Berkeley, CA; Mount Sinai School of Medicine, New York, NY;and University of California Santa Cruz, Santa Cruz, CA). Five Projects and seven Cores are planned. An annual symposium is proposed. Therefore, there is considerable need to coordinate and support the various activities. The Administrative Core A will be responsible for this coordination and support: To coordinate all Program components and ensure communication between Investigators. ? To provide Investigators with help in management of budgets and personnel issues. ? To organize meetings, meeting reports and annual NIH reports. ? To oversee issues related to intellectual property and regulatory issues related to research using human subjects. To provide access to a data management infrastructure.

Public Health Relevance

The proposed U19 program will involve investigators from five different institutions (in Dallas, TX;Berkeley, CA;Santa Cruz, CA;Columbus, OH and New York, NY). The Administrative Core will provide coordination and support for all members ofthe program as well as organize an annual symposium that is funded by this grant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
4U19AI089987-02
Application #
8307077
Study Section
Special Emphasis Panel (ZAI1-QV-I (M2))
Project Start
2011-07-05
Project End
2015-06-30
Budget Start
2011-07-05
Budget End
2012-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$115,125
Indirect Cost
Name
Baylor Research Institute
Department
Type
DUNS #
145745022
City
Dallas
State
TX
Country
United States
Zip Code
75204
Hogstad, Brandon; Berres, Marie-Luise; Chakraborty, Rikhia et al. (2018) RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. J Exp Med 215:319-336
Cepika, Alma-Martina; Banchereau, Romain; Segura, Elodie et al. (2017) A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. J Exp Med 214:3449-3466
Athale, Shruti; Banchereau, Romain; Thompson-Snipes, LuAnn et al. (2017) Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. Sci Transl Med 9:
Banchereau, Romain; Cepika, Alma-Martina; Banchereau, Jacques et al. (2017) Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. Annu Rev Immunol 35:337-370
Silvin, Aymeric; Yu, Chun I; Lahaye, Xavier et al. (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Sci Immunol 2:
Schotsaert, Michael; GarcĂ­a-Sastre, Adolfo (2017) Inactivated influenza virus vaccines: the future of TIV and QIV. Curr Opin Virol 23:102-106
HIPC-CHI Signatures Project Team; HIPC-I Consortium (2017) Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Sci Immunol 2:
Blohmke, Christoph J; Darton, Thomas C; Jones, Claire et al. (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med 213:1061-77
Schmitt, Nathalie; Liu, Yang; Bentebibel, Salah-Eddine et al. (2016) Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans. Cell Rep 16:1082-1095
Bentebibel, Salah-Eddine; Khurana, Surender; Schmitt, Nathalie et al. (2016) ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination. Sci Rep 6:26494

Showing the most recent 10 out of 60 publications