Abstract

The Enterics Research Investigational Network Cooperative Research Center (ERIN CRC) at the University of Washington will be a multisite, multiregional research program under the guidance of the Director Samuel I. Miller and the Administrative Core Leader John Kemner. The Administrative Core of the ERIN CRC will provide strategic planning, oversight and management ofthe program and its resources.
The specific aims of the Administrative Core are to: 1) Organize and manage the resources of the ERIN CRC including a clinical bacterial strain collection, 2) Organize meetings and facilitate communication between components of the ERIN CRC, 3) Facilitate local, regional, national, and international collaborations, 4) Prepare reports and measure outcomes, 5) Manage intellectual property and regulatory issues, and 6) Administer the Research Pilot Projects Program.

Public Health Relevance

The administrative core will assist the ERIN CRC projects in their investigations on the emergence and prevalence of nontypoidal salmonellosis by providing coordination, management, and scientific direction. The Center is investigating mechanisms of prevalence, transmission, and carriage of this disease, specifically comparing conditions on the African continent with the developed world.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090882-04
Application #
8511556
Study Section
Special Emphasis Panel (ZAI1-BLG-M)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$197,970
Indirect Cost
$74,394

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Singletary, Larissa A; Karlinsey, Joyce E; Libby, Stephen J et al. (2016) Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580. MBio 7:e02265
Hayden, Hillary S; Matamouros, Susana; Hager, Kyle R et al. (2016) Genomic Analysis of Salmonella enterica Serovar Typhimurium Characterizes Strain Diversity for Recent U.S. Salmonellosis Cases and Identifies Mutations Linked to Loss of Fitness under Nitrosative and Oxidative Stress. MBio 7:e00154
Akullian, Adam; Ng'eno, Eric; Matheson, Alastair I et al. (2015) Environmental Transmission of Typhoid Fever in an Urban Slum. PLoS Negl Trop Dis 9:e0004212
Pavlinac, Patricia B; Tickell, Kirkby D; Walson, Judd L (2015) Management of diarrhea in HIV-affected infants and children. Expert Rev Anti Infect Ther 13:5-8
LaRock, Doris L; Chaudhary, Anu; Miller, Samuel I (2015) Salmonellae interactions with host processes. Nat Rev Microbiol 13:191-205
Loomis, Wendy P; Johnson, Matthew L; Brasfield, Alicia et al. (2014) Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background. PLoS One 9:e111763
Roxby, Alison C; Unger, Jennifer A; Slyker, Jennifer A et al. (2014) A lifecycle approach to HIV prevention in African women and children. Curr HIV/AIDS Rep 11:119-27
Miller, Claire B; Pierlé, Sebastian Aguilar; Brayton, Kelly A et al. (2014) Transcriptional Profiling of a Cross-Protective Salmonella enterica serovar Typhimurium UK-1 dam Mutant Identifies a Set of Genes More Transcriptionally Active Compared to Wild-Type, and Stably Transcribed across Biologically Relevant Microenvironments. Pathogens 3:417-436
Stewart, Mary K; Cookson, Brad T (2014) Mutually repressing repressor functions and multi-layered cellular heterogeneity regulate the bistable Salmonella fliC census. Mol Microbiol 94:1272-84
Stewart, Mary K; Cookson, Brad T (2012) Non-genetic diversity shapes infectious capacity and host resistance. Trends Microbiol 20:461-6

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