The Administrative Core will facilitate and coordinate communications between the members of the Consortium themselves and between them and the 4 members of the Scientific Advisory Board (SAB), all of whom will be Consultants to the Consortium. The major thrust of the proposals made in this application is to investigate and hopefully resolve the problems associated with coagulation dysregulation following organ xenotransplantation in pig-to-primate models. Frequent communication, most likely in the form of conference calls, is likely to be required between members ofthe Consortium and Consultants, all of whom are experts in the field of xenotransplantation and/or coagulation. The Core will help with travel arrangements and hotel accommodation for Consultants visiting Pittsburgh for the annual workshops at which the results of the Consortium's efforts will be discussed and plans made for the future 12-month period. The Core will also arrange travel and hotels for the members of the Consortium who will be participating in the annual meeting with other scientists funded through this RFA. The immunologic and coagulation assays to be used in the studies in Projects 1 and 2 will, as far as possible, be standardized between the two centers, and this will require exchange of samples, tissues, and reagents. This will be organized and coordinated through the Administrative Core. Data from the various experiments and assays will be collected and collated in the Administrative Core. The Core will also be responsible for assisting with the preparation of manuscripts reporting the scientific work of the consortium to be submitted for publication. The Core will do what it can to ensure timely reporting in peer-reviewed journals ofthe results obtained by the Consortium. It is the Consortium's plan to invite other scientists who are working in this field to the annual workshops that will take place in Pittsburgh, even if those scientists are neither Consultants to the Consortium nor funded by the RFA (although these scientists will have to fund their own travel expenses). The members of the Consortium believe that it is only through full collaboration and exchange of ideas and information that the problems of xenotransplantation will be resolved in a timely manner. The Administrative Core will provide assistance to visiting scientists with regard to reserving hotel accommodation, etc.

Public Health Relevance

This U19 will require significant coordination between the various groups participating in these proposed studies, and it will be greatly advantageous if the PD has administrative assistance to enable him to provide the coordination required. The overall results of the proposed studies are likely to be considerably more informative if the studies have been planned and performed in a coordinated fashion. The studies have the realistic potential to advance xenotransplantation towards clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090959-04
Application #
8514499
Study Section
Special Emphasis Panel (ZAI1-JBS-I)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$42,270
Indirect Cost
$4,180
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Jagdale, Abhijit; Iwase, Hayato; Klein, Edwin et al. (2018) Will donor-derived neoplasia be problematic after clinical pig organ or cell xenotransplantation? Xenotransplantation :e12469
Zhang, Zhongqiang; Hara, Hidetaka; Long, Cassandra et al. (2018) Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells. Transplantation 102:e195-e204
French, Beth M; Sendil, Selin; Sepuru, Krishna Mohan et al. (2018) Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models. Xenotransplantation 25:e12385
Yamamoto, Takayuki; Iwase, Hayato; King, Timothy W et al. (2018) Skin xenotransplantation: Historical review and clinical potential. Burns 44:1738-1749
Li, Qi; Hara, Hidetaka; Zhang, Zhongqiang et al. (2018) Is sensitization to pig antigens detrimental to subsequent allotransplantation? Xenotransplantation 25:e12393
Laird, Christopher T; Hassanein, Wessam; O'Neill, Natalie A et al. (2018) P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage. Xenotransplantation 25:e12381
Zhang, Guoqiang; Hara, Hidetaka; Yamamoto, Takayuki et al. (2018) Serum amyloid a as an indicator of impending xenograft failure: Experimental studies. Int J Surg 60:283-290
Jagdale, Abhijit; Cooper, David K C; Iwase, Hayato et al. (2018) Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantation. Xenotransplantation :e12471
Iwase, Hayato; Yamamoto, Takayuki; Cooper, David K C (2018) Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance? Xenotransplantation :e12472

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