The primary goal of this core is to identify, develop and evaluate promising research efforts that relate to the broad mission of the proposed center at Dartmouth Medical School. Pilot projects to be selected for support under this Core will be those deemed to have the scientific potential for eventual development as independent projects and which are well enough defined in terms of their goals and products to be evaluated at least annually for further funding. We proposed to fund up to two pilot projects per year, for an annual maximum of $50,000 per project, with the potenfial for being renewed once for a total of two years per project. (The total amount awarded under this core, for new or confinuing projects, is $100,000.) Pilot projects that are considered to have a high potenfial for scientific achievement after two years of funding will be considered further for funding in other core budgets and otherwise encouraged and assisted to seek addifional funding. We will solicit proposals for pilot projects, using a variety of methods including the Center's website, direct emailed solicitations of projects internal to Dartmouth Medical School and our collaborating academic institufions, and targeted invitations to potential invesfigators identified by our Pilot Project Scientific Review Committee. The review committee for this pilot project core will consist of the directors of all the cores and the PIs of all the projects plus a distinguished radiation physicist. The review committee will meet annually and as needed to review applications and to evaluate the progress of pilot projects seeking addifional funding.

Public Health Relevance

This pilot project core should add signifciantly to the misison of the CMCRs, seeking out and supporting promising approaches that will advance the capability of effecfively and efficiently carrying out triage after a large scale event. The focus within the cenetr on such dosimetry should provide a very supporting and synergistic pathway to rapid progress

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI091173-02
Application #
8310083
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2011
Total Cost
$423,897
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Swarts, Steven G; Sidabras, Jason W; Grinberg, Oleg et al. (2018) Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry. Health Phys 115:140-150
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2018) Development of a novel mouth model as an alternative tool to test the effectiveness of an in vivo EPR dosimetry system. Phys Med Biol 63:165002
Flood, Ann Barry; Wood, Victoria A; Schreiber, Wilson et al. (2018) Guidance to Transfer 'Bench-Ready' Medical Technology into Usual Clinical Practice: Case Study - Sensors and Spectrometer Used in EPR Oximetry. Adv Exp Med Biol 1072:233-239
Shirley, Ben; Li, Yanxin; Knoll, Joan H M et al. (2017) Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation. J Vis Exp :
Sholom, Sergey; McKeever, Stephen (2017) Stability of X-band EPR signals from fingernails under vacuum storage. Radiat Phys Chem Oxf Engl 1993 141:78-87
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Camarata, Andrew S; Switchenko, Jeffrey M; Demidenko, Eugene et al. (2016) Emesis as a Screening Diagnostic for Low Dose Rate (LDR) Total Body Radiation Exposure. Health Phys 110:391-4
Sholom, S; McKeever, S W S (2016) Emergency EPR dosimetry technique using vacuum-stored dry nails. Radiat Meas 88:41-47
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2016) Evolution and Optimization of Tooth Models for Testing In Vivo EPR Tooth Dosimetry. Radiat Prot Dosimetry 172:152-160
Flood, Ann Barry; Ali, Arif N; Boyle, Holly K et al. (2016) Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods. Health Phys 111:169-82

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