This core provides input from what is generally agreed to be the leading EPR instrumental development site in the world, the National Biomedical EPR Center at the Medical College of Wisconsin (MCW). The role of this core will be to provide leadership in the development of specific aspects of the technology needed to accomplish the goals ofthe CMCR. These developments will be carried out in collaboration with the projects and with the instrumental Core at Dartmouth, to facilitate the development of the best possible o prototype instruments for EPR dosimetry. The contributions ofthe core at MCW are described in four specific aims.
Specific Aim 1 (50% of effort) is the Development of resonators for measurements at X-Band in vivo for nails and teeth;this will be the most extensive project and will focus on exploiting the breakthrough achieved in initial collaborative studies where for the first time, resonators that operate at the very sensitive X-Band frequency were successfully used to make measurements in vivo. This development is at the heart of project 3. During the course of the grant this core will attempt to make analogous resonators that can be used for in vivo tooth dosimetry, which could dramatically improve the already impressive sensitivity of this approach (Project 1).
Specific Aim 2 (25% of effort) - Development of instrumentation to support measurements at X-Band, will especially focus on development of specifically designed microwave bridges that will facilitate both Projects 2 &3. These developments will be carried out in collaboration with a longstanding collaborative partner of both Dr. Hyde and Dr. Swartz, Dr. Froncisz of the Jagiellonian University in Krakow (Dr. Froncisz's support will come via a purchase agreement.
Specific Aim 3 (20% of effort) - Improvements in resonators and bridges for measurements at L-Band. This core will similarly work with Dartmouth and Krakow in the development of improved L-Band bridges, in support of Project 1. It also will facilitate resonator development in project 1 by use ofthe very sophisticated modeling techniques that are highly developed at MCW, which enable different configurations of resonators to e=be rigorously evaluated so that construction can be focused on designs that are likely to be successful Specific Aim 4 -(5 % of effort) support of multifrequency studies will available an exceptional set of EPR spectrometers that can be of value to all three projects in helping to elucidate the characteristics of potentially overlapping components of EPR spectra.

Public Health Relevance

The instruments to be developed in this core will provide unique and valuable additions to the response capabilities of the medical response to an incident in which large numbers of individuals have potentially been exposed to significant amounts of ionizing radiation, enabling scarce resources to be employed more effectively and reducing the level of anxiety in the population

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Dartmouth College
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Flood, Ann Barry; Wood, Victoria A; Schreiber, Wilson et al. (2018) Guidance to Transfer 'Bench-Ready' Medical Technology into Usual Clinical Practice: Case Study - Sensors and Spectrometer Used in EPR Oximetry. Adv Exp Med Biol 1072:233-239
Swarts, Steven G; Sidabras, Jason W; Grinberg, Oleg et al. (2018) Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry. Health Phys 115:140-150
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2018) Development of a novel mouth model as an alternative tool to test the effectiveness of an in vivo EPR dosimetry system. Phys Med Biol 63:165002
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Sholom, Sergey; McKeever, Stephen (2017) Stability of X-band EPR signals from fingernails under vacuum storage. Radiat Phys Chem Oxf Engl 1993 141:78-87
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Camarata, Andrew S; Switchenko, Jeffrey M; Demidenko, Eugene et al. (2016) Emesis as a Screening Diagnostic for Low Dose Rate (LDR) Total Body Radiation Exposure. Health Phys 110:391-4
Sholom, S; McKeever, S W S (2016) Emergency EPR dosimetry technique using vacuum-stored dry nails. Radiat Meas 88:41-47
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2016) Evolution and Optimization of Tooth Models for Testing In Vivo EPR Tooth Dosimetry. Radiat Prot Dosimetry 172:152-160
Flood, Ann Barry; Ali, Arif N; Boyle, Holly K et al. (2016) Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods. Health Phys 111:169-82

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