The proposed U19 will consist of four interdigitating projects that are dependent for success on the integrated scientific interaction among project leaders. For this reason, an Administrative Core is proposed to assist Dr. Reinherz in communications between project leaders and members of their groups, both on-site (DFCI) and off-site (Harvard Medical School, MIT, Northeastern and Duke University Medical School) as well as with various consultants. Because of NIAID participation in collection and analysis of data, obligation for broad data sharing and web-based dissemination of information and methodologies, a well-organized administrative component is essential. The core will facilitate all forms of communication with various project components (phone, email, fax, etc.). The budget will include funds for communication costs, clerical and financial work and for an annual B Cell Immunology Partnership Program Meeting travel for project leaders as well as SAB members to be appointed. Oversight for statistical support, web-based data sharing and dissemination of methodologies relevant to various development efforts are incorporated. An Administrative Partnership Plan and budget to cover the costs of developing a communications network and sponsoring an annual B cell workshop for HIV-1 vaccine discovery are included.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AI091693-05S1
Application #
9055323
Study Section
Special Emphasis Panel (ZAI1-PTM-A)
Program Officer
Shapiro, Stuart Z
Project Start
2015-09-01
Project End
2016-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
5
Fiscal Year
2015
Total Cost
$121,412
Indirect Cost
$51,232
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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Silva, Murillo; Nguyen, Thao H; Philbrook, Phaethon et al. (2017) Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes. Cell Rep 21:3672-3680
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Donius, Luke R; Cheng, Yuxing; Choi, Jaewon et al. (2016) Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J Virol 90:8875-90
Irvine, Darrell J; Hanson, Melissa C; Rakhra, Kavya et al. (2015) Synthetic Nanoparticles for Vaccines and Immunotherapy. Chem Rev 115:11109-46
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