The Lung Biospecimens Core will provide our AADCRC Program with processing of all blood and lung specimens to be collected for each project. This includes all tissue processing, isolation of cells from blood and bronchoalveolar lavage fluid. Isolation of DNA, RNA and miRNA, and performance of bioplex cytokine and chemokine assays. The Core is led by Anne Sperling, PhD, Associate Professor of Medicine, who has extensive experience in the administration of university-wide core facilities and deep familiarity with all the assays and isolations to be performed by this Core. A senior research technologist performs all assays and isolations and maintains rigorous quality control and record-keeping. Timely isolation and storage of biological materials is of the utmost importance in the successful completion of each of the projects in this program. This dedicated Core will meet these obligations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI095230-03
Application #
8503593
Study Section
Special Emphasis Panel (ZAI1-PA-I)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$194,498
Indirect Cost
$70,993
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Stein, Michelle M; Thompson, Emma E; Schoettler, Nathan et al. (2018) A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 142:749-764.e3
Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70
Ober, Carole; Sperling, Anne I; von Mutius, Erika et al. (2017) Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol 48:51-60
White, Steven R; Nicodemus-Johnson, Jessie; Laxman, Bharathi et al. (2017) Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma. J Allergy Clin Immunol 140:857-860
Press, Valerie G; Kelly, Colleen A; Kim, John J et al. (2017) Virtual Teach-To-Goalâ„¢ Adaptive Learning of Inhaler Technique for Inpatients with Asthma or COPD. J Allergy Clin Immunol Pract 5:1032-1039.e1
Krishack, Paulette A; Wang, Kanix; Rzhetsky, Andrey et al. (2017) Preexisting Type 2 Immune Activation Protects against the Development of Sepsis. Am J Respir Cell Mol Biol 57:628-630
Narayanamurthy, Vaishnavi; Sweetnam, John M; Denner, Darcy R et al. (2017) The metabolic footprint of the airway bacterial community in cystic fibrosis. Microbiome 5:67
Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398
Igartua, Catherine; Davenport, Emily R; Gilad, Yoav et al. (2017) Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome 5:16
Ober, Carole (2016) Asthma Genetics in the Post-GWAS Era. Ann Am Thorac Soc 13 Suppl 1:S85-90

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