The Clinical Core (Core D) will be a resource to provide peripheral blood for T cell studies from well characterized allergic rhinitis and asthma subjects to be used in each of the three projects comprising this LIAI U19 Program (Sette, Project 1;Peters, Project 2;Rao, Project 3), To allow the investigation of longitudinal changes in T cell responses in relation to allergen exposure, peripheral blood will be obtained at time points before, during and after the Timothy Grass (TG) pollen season in subjects with seasonal TG induced allergic rhinitis and asthma. In addition to obtaining blood during seasonal exposure to TG, blood will also be collected before and after TG nasal or inhalation allergen challenge in allergic rhinitis and asthma subjects. These studies will determine whether T cell/immune responses are similar or different in allergic rhinitis compared to asthma subjects sensitized to the same allergens. The influence of specific immunotherapy (SIT) with TG on T cell responses will be investigated by obtaining peripheral blood for study before institution of SIT and during the maintenance phase of SIT. These studies will provide insight into both the T cell responses induced by SIT, as well as determine whether there are differences in the T cell response in subjects who are, or are not, desensitized to TG pollen following SIT.

Public Health Relevance

An improved understanding of the immune response to common inhaled allergens such as grass pollen, dust mite, and cat allergens in subjects with sinus allergies and asthma will assist in identifying immune pathways that need to be dampened down to make such allergic patients not have symptoms on exposure to these allergens.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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La Jolla Institute
La Jolla
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Moore, Eugene; Grifoni, Alba; Weiskopf, Daniela et al. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA. Hum Immunol 79:821-822
Schulten, Véronique; Sette, Alessandro (2018) The Identification of Allergen-Derived T Cell Epitopes. Methods Mol Biol 1799:153-163
Schulten, Véronique; Westernberg, Luise; Birrueta, Giovanni et al. (2018) Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma. Front Immunol 9:235
Glesner, Jill; Filep, Stephanie; Vailes, Lisa D et al. (2018) Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine in vitro extract potency for IgE reactivity. J Allergy Clin Immunol :
da Silva Antunes, Ricardo; Pham, John; McMurtrey, Curtis et al. (2018) Urinary Peptides As a Novel Source of T Cell Allergen Epitopes. Front Immunol 9:886
Dhanda, Sandeep Kumar; Karosiene, Edita; Edwards, Lindy et al. (2018) Predicting HLA CD4 Immunogenicity in Human Populations. Front Immunol 9:1369
Schulten, Véronique; Tripple, Victoria; Seumois, Grégory et al. (2018) Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol 141:775-777.e6
Oseroff, Carla; Christensen, Lars H; Westernberg, Luise et al. (2017) Immunoproteomic analysis of house dust mite antigens reveals distinct classes of dominant T cell antigens according to function and serological reactivity. Clin Exp Allergy 47:577-592
Sette, Alessandro; Schulten, Véronique (2017) It's a lot of work to be nonallergic. J Allergy Clin Immunol 139:769-770
Seumois, Grégory; Zapardiel-Gonzalo, Jose; White, Brandie et al. (2016) Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. J Immunol 197:655-64

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