Abstract

The goal of the Metabolomics Core (Core D) is to provide a central resource that will facilitate high throughput characterization of the metabolome in influenza virus infected cells and tissues. We will validate relevant metabolites and localize metabolites within infected tissues samples. The core will also design strategies to uncover host metabolic pathways that are impacted by, and that influence influenza virus infection and disease pathogenesis.

Public Health Relevance

An better understanding of influenza infecfion and pathogenesis requires state-of-the-art tools for measuring the metabolism of infected cells. This Core will perform analysis of small metabolites associated with virus infecfion. These studies will help to define the fundamental ways that influenza causes disease

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI106754-02
Application #
8689908
Study Section
Special Emphasis Panel (ZAI1-EC-M)
Project Start
2014-06-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$347,092
Indirect Cost
$37,092

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Zhao, Nan; Sebastiano, Vittorio; Moshkina, Natasha et al. (2018) Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol 25:885-893
White, Kris M; Abreu Jr, Pablo; Wang, Hui et al. (2018) Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis 4:146-157
Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:7782
Zhang, Liang; Wang, Juan; Muñoz-Moreno, Raquel et al. (2018) Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting. J Virol :
Hancock, Aidan S; Stairiker, Christopher J; Boesteanu, Alina C et al. (2018) Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation. J Virol 92:
Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:2092
Heinz, Sven; Texari, Lorane; Hayes, Michael G B et al. (2018) Transcription Elongation Can Affect Genome 3D Structure. Cell 174:1522-1536.e22
Hartmann, Boris M; Albrecht, Randy A; Zaslavsky, Elena et al. (2017) Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death. Nat Commun 8:1931
Du, Dan; Roguev, Assen; Gordon, David E et al. (2017) Genetic interaction mapping in mammalian cells using CRISPR interference. Nat Methods 14:577-580
Lobingier, Braden T; Hüttenhain, Ruth; Eichel, Kelsie et al. (2017) An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell 169:350-360.e12

Showing the most recent 10 out of 39 publications