The overall objective and goals of the Administrative Core is to manage, coordinate, and supervise all Center activities to effectively and optimally support the Program's goals to develop new classes of host-targeting antiviral therapeutics that are capable of treating multiple NIAID Emerging and Re-emerging Priority Pathogen viruses, when used alone or in combination with other available agents. The Administrative Core will be led by Dr. Jeffrey Glenn as Director, who will anchor the Scientific Advisory Committee composed of Drs. Terrence Blaschke, Gail Cassell, John McHutchison, Charles Rice, Douglas Richman, and Raymond Schinazi as external advisors, and Gary Peltz, Daria Mochly-Rosen, Mark Kay, Vijay Pande, Chaitan Khosia, Purvesh Khatri, and Dr. Harry Greenberg as internal members. The Administrative Core will seek to deliver the above support to both the overall Program and its constituent Projects and Cores via the following specific aims, which are to: 1) Implement administrative &leadership mechanisms via a management plan that will facilitate communication and cooperation among the Project leaders and with the greater consortium and investigators at other institutions so as to ensure a maximally productive research effort; 2) Monitor the progress of each of the research and pilot projects and their interactions with the scientific cores, and promotion of effective communication; 3) Provide an efficient, centralized unit for the appropriate fiscal and administrative operation of the Stanford CETR activities; 4) Provide infrastructure support for the Center investigators to develop collaborative studies with other members of the National CETR Program consortium and research groups.

Public Health Relevance

In summary, we seek to develop new classes of host-targeting antiviral therapeutics that are capable of treating multiple NIAID Emerging and Re-emerging Priority Pathogen viruses, when used alone or in combination with other available agents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109662-01
Application #
8643873
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
2014-04-10
Project End
2019-03-31
Budget Start
2014-04-10
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$203,871
Indirect Cost
$69,367
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Vallania, Francesco; Tam, Andrew; Lofgren, Shane et al. (2018) Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases. Nat Commun 9:4735
Bongen, Erika; Vallania, Francesco; Utz, Paul J et al. (2018) KLRD1-expressing natural killer cells predict influenza susceptibility. Genome Med 10:45
Dovey, Cole M; Diep, Jonathan; Clarke, Bradley P et al. (2018) MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell 70:936-948.e7
Pu, Szu-Yuan; Xiao, Fei; Schor, Stanford et al. (2018) Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment. Antiviral Res 155:67-75
Xiao, Fei; Wang, Stanley; Barouch-Bentov, Rina et al. (2018) Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release. MBio 9:
Sweeney, Timothy E; Azad, Tej D; Donato, Michele et al. (2018) Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. Crit Care Med 46:915-925
Schor, Stanford; Einav, Shirit (2018) Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs. DNA Cell Biol 37:63-69
Cheung, Peggie; Vallania, Francesco; Warsinske, Hayley C et al. (2018) Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell 173:1385-1397.e14
Haynes, Winston A; Tomczak, Aurelie; Khatri, Purvesh (2018) Gene annotation bias impedes biomedical research. Sci Rep 8:1362
Sweeney, Timothy E; Thomas, Neal J; Howrylak, Judie A et al. (2018) Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome. Crit Care Med 46:244-251

Showing the most recent 10 out of 73 publications