The overall objective and goals of the Administrative Core is to manage, coordinate, and supervise all Center activities to effectively and optimally support the Program's goals to develop new classes of host-targeting antiviral therapeutics that are capable of treating multiple NIAID Emerging and Re-emerging Priority Pathogen viruses, when used alone or in combination with other available agents. The Administrative Core will be led by Dr. Jeffrey Glenn as Director, who will anchor the Scientific Advisory Committee composed of Drs. Terrence Blaschke, Gail Cassell, John McHutchison, Charles Rice, Douglas Richman, and Raymond Schinazi as external advisors, and Gary Peltz, Daria Mochly-Rosen, Mark Kay, Vijay Pande, Chaitan Khosia, Purvesh Khatri, and Dr. Harry Greenberg as internal members. The Administrative Core will seek to deliver the above support to both the overall Program and its constituent Projects and Cores via the following specific aims, which are to: 1) Implement administrative & leadership mechanisms via a management plan that will facilitate communication and cooperation among the Project leaders and with the greater consortium and investigators at other institutions so as to ensure a maximally productive research effort; 2) Monitor the progress of each of the research and pilot projects and their interactions with the scientific cores, and promotion of effective communication; 3) Provide an efficient, centralized unit for the appropriate fiscal and administrative operation of the Stanford CETR activities; 4) Provide infrastructure support for the Center investigators to develop collaborative studies with other members of the National CETR Program consortium and research groups.

Public Health Relevance

In summary, we seek to develop new classes of host-targeting antiviral therapeutics that are capable of treating multiple NIAID Emerging and Re-emerging Priority Pathogen viruses, when used alone or in combination with other available agents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI109662-05
Application #
9631967
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Maric, Maja
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Schor, Stanford; Einav, Shirit (2018) Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs. DNA Cell Biol 37:63-69
Cheung, Peggie; Vallania, Francesco; Warsinske, Hayley C et al. (2018) Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell 173:1385-1397.e14
Haynes, Winston A; Tomczak, Aurelie; Khatri, Purvesh (2018) Gene annotation bias impedes biomedical research. Sci Rep 8:1362
Sweeney, Timothy E; Thomas, Neal J; Howrylak, Judie A et al. (2018) Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome. Crit Care Med 46:244-251
Feinberg, Evan N; Sur, Debnil; Wu, Zhenqin et al. (2018) PotentialNet for Molecular Property Prediction. ACS Cent Sci 4:1520-1530
Robinson, Makeda; Schor, Stanford; Barouch-Bentov, Rina et al. (2018) Viral journeys on the intracellular highways. Cell Mol Life Sci 75:3693-3714
Schor, Stanford; Einav, Shirit (2018) Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs. ACS Infect Dis 4:88-92
Sweeney, Timothy E; Wynn, James L; Cernada, MarĂ­a et al. (2018) Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis. J Pediatric Infect Dis Soc 7:129-135
Wu, Zhenqin; Ramsundar, Bharath; Feinberg, Evan N et al. (2018) MoleculeNet: a benchmark for molecular machine learning. Chem Sci 9:513-530
Dudek, Amanda M; Pillay, Sirika; Puschnik, Andreas S et al. (2018) An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor. J Virol 92:

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