The Administrative Core (Core A) will provide the requisite infrastructure to achieve the overall research objectives of the CETR. Effective scientific management and coordination by the Core will provide direction, oversight, and quality control for the research activities of each Project and Core, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long-term relationships. The Administrative Core will promote data sharing, integration of projects, and communication, which will leverage the expertise of each member of the CETR to expedite discovery and achievement of the research goals. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. Each meeting will include discussion and analysis of results, goals and progress, as well as a forum for negotiation of key strategic decisions. The Administrative Core also will foster communication and organizational structure through preparation of financial reports and documents (e.g., progress reports) for the NIH. The Administrative Core will have specific financial responsibilities and obligations particularly as it relates to shared activities among CETR members. This will include costs associated with Scientific Advisory Committee travel and clerical/communication programs directly related to the CETR. Through these activities, the Administrative Core (Core A) will ensure an interactive and collaborative environment, exchange of reagents and data, and foster a cohesive relationship among Pis of the CETR, which will enhance our direct goal of generating novel broad-spectrum anti-infectives against NIAID priority pathogens
Given the size of the CETR, the number of institutions and Investigators, it is absolutely essential to have an umbrella structure provided by the Administrative Core to oversee operations, interchange, and fiscal compliance
| Theisen, Derek J; Davidson 4th, Jesse T; Briseño, Carlos G et al. (2018) WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science 362:694-699 |
| Mohanan, Vishnu; Nakata, Toru; Desch, A Nicole et al. (2018) C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science 359:1161-1166 |
| Chiang, Wei-Chung; Wei, Yongjie; Kuo, Yi-Chun et al. (2018) High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol 13:2247-2260 |
| Peraro, Leila; Deprey, Kirsten L; Moser, Matthew K et al. (2018) Cell Penetration Profiling Using the Chloroalkane Penetration Assay. J Am Chem Soc 140:11360-11369 |
| Nelson, Christopher A; Wilen, Craig B; Dai, Ya-Nan et al. (2018) Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc Natl Acad Sci U S A 115:E9201-E9210 |
| Fernández, Álvaro F; Sebti, Salwa; Wei, Yongjie et al. (2018) Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature 558:136-140 |
| Radke, Joshua B; Burrows, Jeremy N; Goldberg, Daniel E et al. (2018) Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro. ACS Infect Dis 4:1264-1274 |
| Thackray, Larissa B; Handley, Scott A; Gorman, Matthew J et al. (2018) Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections. Cell Rep 22:3440-3453.e6 |
| Lassen, Kara G; Xavier, Ramnik J (2018) Mechanisms and function of autophagy in intestinal disease. Autophagy 14:216-220 |
| Graham, Daniel B; Luo, Chengwei; O'Connell, Daniel J et al. (2018) Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes. Nat Med 24:1762-1772 |
Showing the most recent 10 out of 97 publications
