Abstract

The Data Management, Analysis and Resources Dissemination Core will support the goals of the Broad Genomic Center for Infectious Diseases (GCID) by providing the software infrastructure and tools required for resource and data management, tracking, analysis and dissemination. The Data Core will leverage existing systems and the significant expertise of its personnel to establish and maintain an efficient resource and sample management process, develop a central data management and analysis infrastructure to support the scientific goals of the center, and ensure that high quality data are released rapidly to the scientific community in accordance with NIAID guidelines and instructions. The software infrastructure will flexibly and scalably support large-scale genome assembly, annotation, variant identification, transcriptome reconstruction, phylogenetic and functional comparisons and metagenomic data processing and analysis

Public Health Relevance

The Data Core will be an essential component of the GCID providing the component projects with a set of common production processes supported by a robust compute infrastructure that enables high-throughput sample tracking, metadata and data management, large scale analysis and the rapid release of high quality data and associated resources.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI110818-01
Application #
8710836
Study Section
Special Emphasis Panel ()
Project Start
2014-04-10
Project End
2019-03-31
Budget Start
2014-04-10
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$895,799
Indirect Cost
$326,035

  Institution

Name
Broad Institute, Inc.
Department
Type
DUNS #
623544785
City
Cambridge
State
MA
Country
United States
Zip Code
02142

  Publications

Muñoz, José F; McEwen, Juan G; Clay, Oliver K et al. (2018) Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi. Sci Rep 8:4473
Zhang, Wei; Lun, Shichun; Wang, Shu-Huan et al. (2018) Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors Against Mycobacterium Tuberculosis. J Med Chem :
Rhodes, Johanna; Abdolrasouli, Alireza; Farrer, Rhys A et al. (2018) Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris. Emerg Microbes Infect 7:43
Sephton-Clark, Poppy C S; Muñoz, Jose F; Ballou, Elizabeth R et al. (2018) Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen Rhizopus delemar. mSphere 3:
Ene, Iuliana V; Farrer, Rhys A; Hirakawa, Matthew P et al. (2018) Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen. Proc Natl Acad Sci U S A 115:E8688-E8697
Siddle, Katherine J; Eromon, Philomena; Barnes, Kayla G et al. (2018) Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018. N Engl J Med 379:1745-1753
Brennan-Krohn, Thea; Pironti, Alejandro; Kirby, James E (2018) Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother 62:
Messina, Julia A; Wolfe, Cameron R; Hemmersbach-Miller, Marion et al. (2018) Genomic characterization of recurrent mold infections in thoracic transplant recipients. Transpl Infect Dis 20:e12935
Schaffner, Stephen F; Taylor, Aimee R; Wong, Wesley et al. (2018) hmmIBD: software to infer pairwise identity by descent between haploid genotypes. Malar J 17:196
Farrer, Rhys A; Ford, Christopher B; Rhodes, Johanna et al. (2018) Transcriptional Heterogeneity of Cryptococcus gattii VGII Compared with Non-VGII Lineages Underpins Key Pathogenicity Pathways. mSphere 3:

Showing the most recent 10 out of 95 publications