The Administrative Core will be led by Jeffrey Ravetch, M.D., Ph.D. (CCHI Director, Administrative Core Leader, and Project 1 Leader), who has space in the Laboratory of Molecular Genetics and Immunology at The Rockefeller University. The primary objectives of this Core are to provide administrative, compliance, and financial oversight, provide scientific direction, and create and facilitate clear and efficient communication to the entire CCHI. The role of the Administrative Core includes evaluating and coordinating progress in all four scientific projects by arranging meetings and other scientific exchanges, encouraging steamlined interactions with the proposed Service, Pilot, and Opportunity Fund Management Cores. The goals of the Core include 1) evaluating and coordinating progress on all four scientific projects, 2) establishing the External Scientific Advisory Group and disseminating recommendations for improvement or advancement, 3) creating and maintaining mechanisms for CCHI-related and field-related updates via a website, annual seminars, and monthly teleconferences, and 4) ensuring fiscal and compliance accountability throughout the life of the Center. The Administrative Core will also be responsible for coordinating internal and external leadership and advisory committees and assisting all investigators with manuscript preparation and annual progress reports. As part of the Administrative Core, a website will be built (linked to The Rockefeller University website) that gives updates, which will be available to the public, on progress and publications generated from the CCHI. The website will also include a password-protected component that will enable data dissemination to all projects to internal CCHI members. To encourage the ongoing exchange of ideas and information in the scientific field, the Administrative Core will also propose and manage an annual seminar held at The Rockefeller University.
Our program is highly integrated and is based on long-term, productive collaborations between the PIs aimed at defining underlying principles of human immunology. The Administrative Core will synergize the efforts and progress from the leadership team and will act as the coordinating center for the CCHI, establishing external committees and internal best practices.
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| Wu, Xianfang; Dao Thi, Viet Loan; Huang, Yumin et al. (2018) Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell 172:423-438.e25 |
| Hernandez, Nicholas; Melki, Isabelle; Jing, Huie et al. (2018) Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency. J Exp Med 215:2567-2585 |
| Rosenberg, Brad R; Freije, Catherine A; Imanaka, Naoko et al. (2018) Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients. J Infect Dis 217:650-655 |
| Wang, Taia T; Bournazos, Stylianos; Ravetch, Jeffrey V (2018) Immunological responses to influenza vaccination: lessons for improving vaccine efficacy. Curr Opin Immunol 53:124-129 |
| Kenney, Adam D; Dowdle, James A; Bozzacco, Leonia et al. (2017) Human Genetic Determinants of Viral Diseases. Annu Rev Genet 51:241-263 |
| Bournazos, Stylianos; Ravetch, Jeffrey V (2017) Fc? Receptor Function and the Design of Vaccination Strategies. Immunity 47:224-233 |
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| Wang, Taia T; Sewatanon, Jaturong; Memoli, Matthew J et al. (2017) IgG antibodies to dengue enhanced for Fc?RIIIA binding determine disease severity. Science 355:395-398 |
| Maamary, Jad; Wang, Taia T; Tan, Gene S et al. (2017) Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization. Proc Natl Acad Sci U S A 114:10172-10177 |
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