- EPIC-STI BIOSTATISTICS AND BIOINFORMATICS CORE (BBC) (CUZICK/WHEELER) The Biostatistics and Bioinformatics Core (BBC) provides support with design, data management and analysis of research studies for the Epidemiology Prevention Interdisciplinary Center for Sexually Transmitted Infections (EPIC-STI). Moreover, it serves as a centralized resource for biostatistical consulting, methods development and analyses for scientific projects. The unit provides a centralized analytic base to each of the four scientific projects as well as new pilot developmental research projects at all levels of investigation, beginning with the formulation of more specific hypotheses related to the overall unifying hypotheses, reviewing study designs, and evaluating the utility of measurement techniques. Support and consultation concludes with aiding in the interpretation, presentation, and final writing of results. The EPIC-STI BBC also serves to warehouse and maintain a public health population-based data resource, the New Mexico HPV Pap Registry (NMHPVPR), a cornerstone of the overall EPIC-STI and a model of integrated health informatics. The BBC will promote the EPIC-STI research aims as follows: 1) finalize the study designs and protocols in collaboration with each study investigator; 2) mentor, train and foster exchange programs for junior investigators transitioning toward careers in STI research; 3) collaborate with the study investigators in the development of data collection instruments and applications; 3) assist in development of protocols for secure data transmission; 4) collaborate with the study investigators in developing detailed study manuals; 5) develop and manage the EPIC-STI central and project-specific relational databases including the NMHPVPR; 6) run SAS quality-control program checks; 7) maintain a Master Database for each project with appropriate backups and security checks; 8) monitor study progress and distribute quarterly reports; 9) produce reports summarizing data acquisition by subject, distributions and summary statistics for the primary variables; 10) interface and perform linkages to the New Mexico state-wide immunization information system (NM-SIIS) and other administrative and statistics data sources; 11) perform basic, complex and exploratory statistical analyses; 12) develop new methods for analysis of complex datasets; and 13) develop and maintain the EPIC-STI web site and portals.

Public Health Relevance

- EPIC-STI BIOSTATISTICS AND BIOINFORMATICS CORE (BBC) (CUZICK/WHEELER) The Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Infections (EPIC-STI) focuses on the most common STI agents, human papillomavirus (HPV) and Chlamydia trachomatis (CT). To maximally realize improvements in HPV and CT prevention, basic biological discovery, technology and methodologic advances, molecular epidemiology and population effectiveness is partnered across laboratory, clinical & real-world setting.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI113187-02
Application #
8878171
Study Section
Special Emphasis Panel (ZAI1-MFH-M)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
2
Fiscal Year
2015
Total Cost
$493,106
Indirect Cost
$134,980
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Lijek, Rebeccah S; Helble, Jennifer D; Olive, Andrew J et al. (2018) Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populations. Proc Natl Acad Sci U S A 115:2216-2221
Frietze, Kathryn M; Lijek, Rebeccah; Chackerian, Bryce (2018) Applying lessons from human papillomavirus vaccines to the development of vaccines against Chlamydia trachomatis. Expert Rev Vaccines 17:959-966
Yokoyama, Christine C; Baldridge, Megan T; Leung, Daisy W et al. (2018) LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem 293:6022-6038
Castle, Philip E; Wheeler, Cosette M; Campos, Nicole G et al. (2018) Inefficiencies of over-screening and under-screening for cervical cancer prevention in the U.S. Prev Med 111:177-179
Arrossi, Silvina; Temin, Sarah; Garland, Suzanne et al. (2017) Primary Prevention of Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Guideline. J Glob Oncol 3:611-634
Zhai, Lukai; Peabody, Julianne; Pang, Yuk-Ying Susana et al. (2017) A novel candidate HPV vaccine: MS2 phage VLP displaying a tandem HPV L2 peptide offers similar protection in mice to Gardasil-9. Antiviral Res 147:116-123
Ramírez-Peinado, Silvia; Ignashkova, Tatiana I; van Raam, Bram J et al. (2017) TRAPPC13 modulates autophagy and the response to Golgi stress. J Cell Sci 130:2251-2265
Cuzick, Jack; Myers, Orrin; Lee, Ji-Hyun et al. (2017) Outcomes in Women With Cytology Showing Atypical Squamous Cells of Undetermined Significance With vs Without Human Papillomavirus Testing. JAMA Oncol 3:1327-1334
Peabody, Julianne; Muttil, Pavan; Chackerian, Bryce et al. (2017) Characterization of a spray-dried candidate HPV L2-VLP vaccine stored for multiple years at room temperature. Papillomavirus Res 3:116-120
Laborde, Rady J; Sanchez-Ferras, Oraly; Luzardo, María C et al. (2017) Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response. J Immunol 198:2772-2784

Showing the most recent 10 out of 18 publications