This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The Administrative Core will be responsible for managing, coordinating, and supervising the entire range of SCRIPT Systems Biology Center activities. As such, the Administrative Core will intersect with all internal SCRIPT investigators as well as the NIAID sponsoring agency, other Systems Biology Centers, and the broader infectious diseases and pulmonary/critical care scientific communities. The SCRIPT Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The Administrative Core will accomplish these objectives in three interrelated specific aims:
AIM 1. To provide the administrative and organizational infrastructure to facilitate accomplishment of the SCRIPT goals within proposed timelines, and to disseminate the output of the Research Projects and Cores. This will include the submission of SCRIPT Systems Biology Center output to NIAID-directed public databases/repositories.
AIM 2. To coordinate and integrate the two SCRIPT Systems Biology Center Research Projects.
AIM 3. To organize local and external outreach programs to promote a systems biology approach to infectious pneumonia. This includes integration of the SCRIPT Systems Biology Center into current local training programs, submission of an application to Gordon Research Conference or similar conference for a research symposium on a systems biology approach to pneumonia and a proposal to the American Thoracic Society for a post graduate course on Systems Biology Approaches to Pneumonia. The major premise of the SCRIPT Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. Investigators in the Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia researchers.

Public Health Relevance

It is not required per instructions stated on the Funding Opportunity Announcement RFA-AI-16-080, Section IV. Application and Submission Information, Administrative Core, Research & Related Other Project Information (Administrative Core), ?Project Narrative: Do not complete?.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI135964-01
Application #
9454819
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-01-17
Budget End
2018-12-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Walter, James M; Wunderink, Richard G (2018) Testing for Respiratory Viruses in Adults With Severe Lower Respiratory Infection. Chest 154:1213-1222
Sala, Marc A; Balderas-Martínez, Yalbi Itzel; Buendía-Roldan, Ivette et al. (2018) Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis. Respir Res 19:233
Walter, James M; Helmin, Kathryn A; Abdala-Valencia, Hiam et al. (2018) Multidimensional assessment of alveolar T cells in critically ill patients. JCI Insight 3:
Ozer, Egon A (2018) ClustAGE: a tool for clustering and distribution analysis of bacterial accessory genomic elements. BMC Bioinformatics 19:150
Morales-Nebreda, Luisa; McLafferty, Fred S; Singer, Benjamin D (2018) DNA methylation as a transcriptional regulator of the immune system. Transl Res :
Katoh, Masaru (2018) Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review). Int J Mol Med 42:713-725
Rutherford, Victoria; Yom, Kelly; Ozer, Egon A et al. (2018) Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa. Environ Microbiol Rep 10:485-492
Ozer, Egon A; Hauser, Alan R; Gerding, Dale N et al. (2017) Complete Genome Sequence of Clostridioides difficile Epidemic Strain DH/NAP11/106/ST-42, Isolated from Stool from a Pediatric Patient with Diarrhea. Genome Announc 5: