Viralhemorrhagicfevers,ofwhichEbolavirus(EBOV)andLassavirus(LASV)areprototypicalexamples,area major source of human su?ering. Recent outbreaks have raised concerns about the possibility of a global outbreak.TheultimategoaloftheConsortiumforViralSystemsBiology(CViSB)istode?nenetworksofhost and viral factors that drive clinical outcomes in Ebola virus disease (EVD) and Lassa fever (LF). The responsibilities and contributions of the Technology Core fall into three main categories: data generation, technology development and standardization, and evaluation and incorporation of emerging technologies. Althoughthesecategoriesaredistinct,theyaretightlyintegrated.TheCore?sroleasdatagenerationhubfor CViSB also mandates that we continually work to develop and improve our methods and to rapidly incorporatenoveltechnologicaladvancestoensurethatweremainastate-of-the-art,productivememberof the Center. The Technology Core?s Aims are focused onthedevelopment,adaptationandstandardizationofinnovative experimental approaches in four main areas: (1) deep characterization of theadaptiveimmuneresponseto infection, (2) functional pro?ling of antiviral serum activity, (3) isolation and characterization of protective monoclonalantibodiesand(4)cost-e?cientviralgenomesequencing.InadditiontosupportingtheCenter?s ProjectsandcontributingtotheoverallsuccessofCViSB,theTechnologyCorewilltranslateits technicaland methodological advances into standardized, reproducible protocols that will bene?t other Centers and the broader infectious disease community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI135995-01
Application #
9455505
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2018-02-01
Project End
2023-01-31
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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