The Graduate School of Biomedical Sciences (GSBS) is collaborating with the Texas College of Osteopathic Medicine (TCOM) and the Arizona College of Osteopathic Medicine (AZCOM) in order to develop a Developmental Center for Research on Osteopathic Manipulative Medicine (DCR-OMM). OMM is a body-based therapy as defined by the NCCAM definitions of complementary and alternative medicine (CAM). The varied principles and practices of OMM are unique among other body-based therapies primarily because they are applied by fully licensed physicians and therefore can be applied to alleviate both musculoskeletal and visceral disease processes and readily integrated with conventional health care. Four key elements of osteopathic principles and practices will be investigated in this DCR-OMM: 1) Effects of direct biomechanical strain on the fascial tissues of the musculoskeletal system (Study #1); 2) Effects of OMM (lymphatic pump) on the lymphatic duct lymph flow and the resultant potential beneficial effects on edema and immune function subsequent to an improvement in lymphatic circulation (Study #2); 3) Effects of OMM on sympathetic neural activity either by affecting the sympathetic nervous system directly or by affecting the sympathetic nervous system indirectly by reduction of somatic dysfunction induced pain (Study #3); and 4) Combined synergistic clinical outcome effects which result from applying OMM in patients post-CABG who have a complex combination of fascial restrictions, pathologic fluid shifts, somatic pain and hypersympathotonia (Study #4). In 2001, the leading national osteopathic professional organizations endorsed and funded these investigators to establish a national Osteopathic Research Center (ORC) housed within the Physical Medicine Institute at the University of North Texas Health Science Center. The OMM research and research training missions of the ORC, supported in part by a 5-year NIH NCCAM K-30 OMM clinical research training grant, are perfectly aligned with the goals of the U-19 DCR-OMM. We are all dedicated to the success of this DCR-OMM with the express goal of developing into a P-01 Center of Excellence for Research on OMM to enable quality investigation and publication of the mechanisms of OMM.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AT002023-03S1
Application #
7596082
Study Section
Special Emphasis Panel (ZAT1-DB (14))
Program Officer
Khalsa, Partap Singh
Project Start
2004-09-30
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2010-08-31
Support Year
3
Fiscal Year
2008
Total Cost
$770,624
Indirect Cost
Name
University of North Texas
Department
Physiology
Type
Other Domestic Higher Education
DUNS #
110091808
City
Fort Worth
State
TX
Country
United States
Zip Code
76107
Hensel, Kendi L; Pacchia, Christina F; Smith, Michael L (2013) Acute improvement in hemodynamic control after osteopathic manipulative treatment in the third trimester of pregnancy. Complement Ther Med 21:618-26
Cao, Thanh V; Hicks, Michael R; Standley, Paul R (2013) In vitro biomechanical strain regulation of fibroblast wound healing. J Am Osteopath Assoc 113:806-18
Giles, Paul D; Hensel, Kendi L; Pacchia, Christina F et al. (2013) Suboccipital decompression enhances heart rate variability indices of cardiac control in healthy subjects. J Altern Complement Med 19:92-6
Schander, Artur; Downey, H Fred; Hodge, Lisa M (2012) Lymphatic pump manipulation mobilizes inflammatory mediators into lymphatic circulation. Exp Biol Med (Maywood) 237:58-63
Hodge, Lisa M; Downey, H Fred (2011) Lymphatic pump treatment enhances the lymphatic and immune systems. Exp Biol Med (Maywood) 236:1109-15
Meltzer, Kate R; Cao, Thanh V; Schad, Joseph F et al. (2010) In vitro modeling of repetitive motion injury and myofascial release. J Bodyw Mov Ther 14:162-71
Hodge, Lisa M; Bearden, Melissa K; Schander, Artur et al. (2010) Lymphatic pump treatment mobilizes leukocytes from the gut associated lymphoid tissue into lymph. Lymphat Res Biol 8:103-10
Prajapati, Parna; Shah, Pankhil; King, Hollis H et al. (2010) Lymphatic pump treatment increases thoracic duct lymph flow in conscious dogs with edema due to constriction of the inferior vena cava. Lymphat Res Biol 8:149-54
Standley, Paul R; Meltzer, Kate (2008) In vitro modeling of repetitive motion strain and manual medicine treatments: potential roles for pro- and anti-inflammatory cytokines. J Bodyw Mov Ther 12:201-3
Downey, H Fred; Durgam, Preethi; Williams Jr, Arthur G et al. (2008) Lymph flow in the thoracic duct of conscious dogs during lymphatic pump treatment, exercise, and expansion of extracellular fluid volume. Lymphat Res Biol 6:3-13

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