Purpose: The Bastyr University/University of Washington PCCTR Oncomycology Research Center will investigate the immunologic and antitumor effects of Trametes versicolor (Tv) a traditional Chinese medicine medicinal mushroom, for use in the treatment of cancer patients in the US. The past 6 years of research at our NCCAM-funded Developmental Center for Research in CAM (DCRC) led us to conclude that the immunomodulating mushroom Tv, widely used by Japanese oncologists, may be an effective adjunctive immune therapy because of its targeted activation of the innate and adaptive immune system via TOll-lil

Public Health Relevance

The Asian medicinal mushroom, Trametes versicolor (PSK), is a potentially important immune therapy for breast and prostate cancer. The DCRC center (2005-2009) elucidated the TLR mechanism of action of PSK. In the next 4 years of the PCCTR center we will be the first to conduct clinical trials of PSK in US cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AT006028-02S1
Application #
8251308
Study Section
Special Emphasis Panel (ZAT1-SM (20))
Program Officer
Pontzer, Carol H
Project Start
2010-09-29
Project End
2014-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2011
Total Cost
$134,898
Indirect Cost
Name
Bastyr University
Department
Type
Organized Research Units
DUNS #
055652309
City
Kenmore
State
WA
Country
United States
Zip Code
98028
Quayle, Kenneth; Coy, Catherine; Standish, Leanna et al. (2015) The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound ?-glucan. J Nat Med 69:198-208
Coy, Catherine; Standish, Leanna J; Bender, Geoff et al. (2015) Significant Correlation between TLR2 Agonist Activity and TNF-? Induction in J774.A1 Macrophage Cells by Different Medicinal Mushroom Products. Int J Med Mushrooms 17:713-22
Yang, Yi; Inatsuka, Carol; Gad, Ekram et al. (2014) Protein-bound polysaccharide-K induces IL-1? via TLR2 and NLRP3 inflammasome activation. Innate Immun 20:857-66
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Inatsuka, Carol; Yang, Yi; Gad, Ekram et al. (2013) Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK. Cancer Immunol Immunother 62:1335-45
Wenner, Cynthia A; Martzen, Mark R; Lu, Hailing et al. (2012) Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer. Int J Oncol 40:905-13
Lu, Hailing; Yang, Yi; Gad, Ekram et al. (2011) TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy. Clin Cancer Res 17:6742-53
Lu, Hailing; Yang, Yi; Gad, Ekram et al. (2011) Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res 17:67-76